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ProteomicsProtein kinase A phosphorylation of perilipin 5 on serine 155 regulates liver lipolysis via interactions with adipose triglyceride lipase
Perilipin (PLIN) 5 is a lipid droplet-associated protein that coordinates intracellular lipolysis in highly oxidative tissues and is thought to regulate lipid metabolism in response to phosphorylation by protein kinase A (PKA). We detected phosphorylation on S155, S161 and S163 of recombinant PLIN5 ...
ORGANISM(S): Mus musculus (Mouse) 
2021-03-11 | PXD021969 | Pride
Lipid droplets Fatty acid Perilipin Lipase Triglycerides Lipid metabolism Phosphorylation 
ProteomicsTermination of STING responses is mediated via ESCRT-dependent degradation
The cGAS-STING pathway forms a major component of the innate immune system. cGAS-STING signalling is induced by detection of either foreign (i.e. pathogenic) or mislocalised host double stranded (ds)DNA present within the cytosol. STING acts as the major signalling hub, where it controls activation ...
ORGANISM(S): Mus musculus (Mouse) 
2023-05-05 | PXD037108 | Pride
Cgas-sting/escrt/innate immunity/lysosomal degradation/vesicular trafficking 
ProteomicsHepatic processing of Z variant α-1-antitrypsin alters ERAD capacity to regulate cholesterol biosynthesis in a zebrafish model
Homozygosity for the Z allele of α1-antitrypsin (ZAAT) predisposes affected individuals to developing liver disease as the serpin misfolds and forms insoluble polymers that accumulate in the endoplasmic reticulum (ER) of hepatocytes, resulting in gain-of-function hepatotoxicity. This prevents secret...
ORGANISM(S): Danio rerio (Zebrafish) (Brachydanio rerio) 
2023-03-10 | PXD036830 | Pride
Alpha-1-antitrypsin  serpina1  zebrafish  liver  erad 
ProteomicsProteomic Identification of Interferon-induced Proteins with Tetratricopeptide Repeats (IFITs) as Markers of M1 Macrophage Polarization
Proteomic studies of macrophage polarization to pro-inflammatory (M1) or tissue reparative (M2) phenotypes has identified interferon-induced proteins with tetratricopeptide repeats (IFIT1, IFIT2 and IFIT3) as potential biomarkers of inflammatory diseases such as atherosclerosis.
ORGANISM(S): Homo sapiens (Human) 
2018-03-15 | PXD008204 | Pride
Lc ms/ms Lfq Thp-1 macrophage polarisation Ifit 
ProteomicsProteotranscriptomic profiling of potential E6AP targets
Prostate cancer is a common cause of cancer-related death in men. E6AP, an E3 ubiquitin ligase and a transcription cofactor, is elevated in a subset of prostate cancer patients. Genetic manipulations of E6AP in prostate cancer cells expose a role of E6AP in promoting growth and survival of prostate ...
ORGANISM(S): Homo sapiens (Human) 
2018-02-27 | PXD008743 | Pride
E6ap Clusterin Prostate cancer Silac Transcriptomics 
ProteomicsBS3 intermolecular crosslinking map of SAGA and SLIK (SAGA-like) transcription coactivators
The SAGA-like complex SLIK is a modified version of the Spt-Ada-Gcn5-Acetyltransferase (SAGA) complex. SLIK is formed through C-terminal truncation of the Spt7 SAGA subunit, causing loss of Spt8 that interacts with the TATA-binding protein. SLIK and SAGA are both coactivators of RNA polymerase II tr...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2021-04-19 | PXD024640 | Pride
Dna-protein interaction Cryo-electron microscopy Histone deubiquitination Transcriptional coactivator Histone acetylation 
ProteomicsPhosphoproteomics-directed manipulation reveals SEC22B as an hepatocellular signaling node governing metabolic actions of glucagon
The peptide hormone glucagon is a fundamental metabolic regulator that is also being considered as a pharmocotherapeutic option for obesity and type 2 diabetes. Despite this, we know very little of how glucagon exerts its pleiotropic metabolic actions. Given that the liver is a chief site of action,...
ORGANISM(S): Mus musculus (Mouse) 
2024-08-29 | PXD049186 | Pride
Sec22b Liver Mass spectrometry Glucagon Phosphoproteomics 
ProteomicsProteotranscriptomic profiling of potential E6AP targets
Prostate cancer is a common cause of cancer-related death in men. E6AP, an E3 ubiquitin ligase and a transcription cofactor, is elevated in a subset of prostate cancer patients. Genetic manipulations of E6AP in prostate cancer cells expose a role of E6AP in promoting growth and survival of prostate ...
ORGANISM(S): Homo sapiens (Human) 
2021-03-11 | PXD008132 | Pride
E6ap Clusterin Prostate cancer Silac Transcriptomics 
ProteomicsMicroglia display altered spatial morphology and proteome after stroke
Microglia are abundantly distributed throughout the central nervous system (CNS) to play critical roles in neural development and homeostasis, and act as immune sentinels to constantly monitor their surrounding neural environment. Given their high reactivity to brain insults, we hypothesised that th...
ORGANISM(S): Mus musculus (Mouse) 
2025-12-22 | PXD055588 | Pride
Stroke Neuroinflammation Proteome Mouse Morphology Microglia 
ProteomicsMast cell-derived SAMD14 is a novel regulator of the human prostate tumor microenvironment
Mast cells (MCs) are important cellular components of the tumor microenvironment and are significantly associated with poor patient outcomes in prostate cancer and other solid cancers. The promotion of tumor progression partly involves heterotypic interactions between MCs and cancer-associated fibro...
ORGANISM(S): Homo sapiens (Human) 
2021-03-12 | PXD022782 | Pride
Prostate cancer  tumor microenvironment  mast cells  samd14  cancer-associated fibroblasts  extracellular matrix 
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