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ProteomicsID3 Promotes Homologous Recombination via Non-transcriptional and Transcriptional Mechanisms and its loss confers Sensitivity to PARP
The inhibitor of DNA-binding 3 (ID3) is a transcriptional regulator that limits interaction of basic helix-loop-helix transcription factors with the DNA. ID3 expression is frequently deregulated in human cancers and its loss was shown to impact DNA repair. To understand the molecular mechanisms by w...
ORGANISM(S): Homo sapiens (Human) 
2025-04-08 | PXD023106 | Pride
Cancer Id3 Hdr Parpi Dsb 
ProteomicsID3 Promotes Homologous Recombination via Non-transcriptional and Transcriptional Mechanisms and its Loss Confers Sensitivity to PARP Inhibition
The inhibitor of DNA-binding 3 (ID3) is a transcriptional regulator that limits interaction of basic helix-loop-helix transcription factors with their target DNA sequences. We previously reported that ID3 loss is associated with mutational signatures linked to DNA repair defects. Here we demonstrate...
ORGANISM(S): Homo sapiens (Human) 
2022-02-17 | PXD028946 | Pride
Dsbs Dna repair Cell sensitivity Id3 Hr Parpi 
ProteomicsARID1A regulates chromatin organization and establishment of epigenetic marks for DSB repair and transcription silencing
AT-rich interactive domain-containing protein 1A (ARID1A), a SWI/SNF chromatin remodeling complex subunit, is frequently mutated across various cancer entities. ARID1A contributes to DNA damage response pathways, and we previously reported that ARID1A loss is associated with mutational signatures li...
ORGANISM(S): Homo sapiens (Human) 
2025-04-08 | PXD046159 | Pride
Epigenetics Hr Arid1a Dsb Chromatin 
TranscriptomicsComprehensive genomic analysis of relapse neuroblastoma [methylation]
Relapse neuroblastoma were characterized by sequencing, gene expression, arrayCGH and genome-wide methylation. This data set contains genome-wide methylation data. Array from tumours at relapse were compared to pretreatment tumours and corresponding normal samples.
ORGANISM(S): Homo sapiens 
2015-06-19 | E-GEOD-65306 | biostudies-arrayexpress
TranscriptomicsA radiation-induced gene expression signature as a tool to predict acute radiotherapy-induced adverse side effects
The majority of patients tolerate radiotherapy well, but some of them suffer from severe side effects. To find genes possibly predictive for radiosensitivity, mRNA profiles were generated before and 6 h after in vitro irradiation with 5 Gy. We analyzed lymphocytes from four head and neck and eight b...
ORGANISM(S): Homo sapiens 
2012-09-06 | E-GEOD-40640 | biostudies-arrayexpress
TranscriptomicsRNA expression data from primary neuroblastoma tumors
RNA expression profiles of 105 primary neuroblastomas derived from customized 4 x 44k oligonucleotide microarrays (Agilent Technologies). These profiles are part of an integrative study combining genomewide epigenetic profiles with transcriptome data of the same neuroblastoma cohort. Tumors were der...
ORGANISM(S): Homo sapiens 
2016-09-08 | E-GEOD-73517 | biostudies-arrayexpress
TranscriptomicsDNA methylation data from primary neuroblastoma tumors
Genome wide DNA methylation profiling of primary neuroblastomas. The Illumina 450k methylation array was used to obtain DNA methylation profiles across approximately 485,000 CpGs in 105 neuroblastomas. Tumors were derived from 40 low-risk, 9 intermediate-risk and 56 high-risk patients. Bisulphite c...
ORGANISM(S): Homo sapiens 
2016-09-08 | E-GEOD-73515 | biostudies-arrayexpress
ProteomicsARID1A regulates chromatin organization and establishment of epigenetic marks for DSB repair and transcription silencing
AT-rich interactive domain-containing protein 1A (ARID1A), a SWI/SNF chromatin remodeling complex subunit, is frequently mutated across various cancer entities. ARID1A contributes to DNA damage response pathways, and we previously reported that ARID1A loss is associated with mutational signatures li...
ORGANISM(S): Homo sapiens (Human) 
2024-06-22 | PXD047225 | Pride
Dsb repair Epigenetic regulation Arid1a Chromatin 
TranscriptomicsEarly Epigenetic Downregulation of Tumor Suppressor WNK2 during Pancreatic Ductal Adenocarcinoma Development
BACKGROUND & AIMS: Pancreatic ductal adenocarcinoma (PDAC) is usually incurable. Contrary to genetic mechanisms involved in PDAC pathogenesis, epigenetic alterations are ill defined. Here we determine the contribution of epigenetically silenced genes to the development of PDAC. METHODS: We invest...
ORGANISM(S): Homo sapiens 
2012-11-01 | E-GEOD-37480 | biostudies-arrayexpress
Genomicsena-DATASET-UKEssen-09-09-2015-10:54:33:815-144 - samples
In this dataset, 16 trios- primary tumor, relapse and corresponding normals- for patients with neuroblastoma are provided. For one patient, more than one relapse was available for the analyses.
EGAD00001001607 | EGA
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