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ProteomicsQuantitative proteomics reveals the role of arginine phosphorylation in bacterial stress response
Application of a novel TiO2-based phosphopeptide enrichment protocol to study the role of protein arginine phosphorylation in B.subtilis. 1 iTRAQ Quantification of pArg peptides in B.subtilis upon heat shock and oxidative stress in comparison to unstressed control 2 Studying pArg upon deletion of M...
ORGANISM(S): Bacillus subtilis subsp. subtilis str. 168 
2013-11-21 | PXD000273 | Pride
Stress response Arginine phosphorylation Bacillus subtilis 
ProteomicsProteolytic processing of CD99
The adhesion molecule CD99 is essential for transendothelial migration (TEM) of leukocytes. Here we demonstrate by biochemical and cellular assays that CD99 undergoes ectodomain shedding by the metalloprotease meprin ? and subsequent intramembrane proteolysis by ?-secretase. The cleavage site in CD9...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-29 | MSV000080746 | MassIVE
TranscriptomicsTranscription profiling of fission yeast strains designed to make swi5-based mapping more efficient and powerful
Fission yeast genes identified in genetic screens are usually cloned by transformation of mutants with plasmid libraries. However, for some genes this can be difficult, and positional cloning approaches are required. The mutation swi5-39 reduces recombination frequency in homozygous crosses and ha...
ORGANISM(S): Schizosaccharomyces pombe 
2008-07-04 | E-TABM-517 | biostudies-arrayexpress
ProteomicsIdentifying SAM-binding proteins in D.melanogaster
The aim of the project is to identify proteins the ustilize S-adenosyl methionine as cofactor for performing methylation of target molecules in D. melanogaster S2 cells. For this purpose, we applied a small-molecule capturing protocol using a SAH-capture compound with UV-activated crosslinker and bi...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2019-03-11 | PXD005012 | Pride
Capture compound Fragmentation Methylation S-adenosyl methionine 
ProteomicsExome reanalysis and proteomic profiling identified TRIP4 as a novel cause of cerebellar hypoplasia and spinal muscular atrophy (PCH1)
TRIP4 is one of the subunits of the transcriptional coregulator ASC-1, a ribonucleoprotein complex that participates in transcriptional coactivation and RNA processing events. Recessive variants in the TRIP4 gene have been associated with spinal muscular atrophy with bone fractures as well as a sev...
ORGANISM(S): Homo sapiens (Human) 
2022-02-16 | PXD023584 | Pride
Proteogenomics Pch1 Solve-rd Exome reanalysis Trip4 
ProteomicsProtein signature of human skin fibroblasts indicates the suitability to serve as in vitro model for neuromuscular diseases (AAAS-Data)
The elucidation of pathomechanisms leading to the manifestation of neuromuscular diseases (NMDs) represents an important step toward the understanding of the genesis of the respective disease and might help to define starting points for (new) therapeutic intervention concepts. However, these “discov...
ORGANISM(S): Homo sapiens (Human) 
2020-11-10 | PXD019201 | Pride
Allgrove syndrome Aladin Aaas Myopodin/synaptopodin-2 Triple-a syndrome Ataxin-2 
ProteomicsProtein signature of human skin fibroblasts indicates the suitability to serve as in vitro model for neuromuscular diseases (Library Data)
The elucidation of pathomechanisms leading to the manifestation of neuromuscular diseases (NMDs) represents an important step toward the understanding of the genesis of the respective disease and might help to define starting points for (new) therapeutic intervention concepts. However, these “discov...
ORGANISM(S): Homo sapiens (Human) 
2020-11-10 | PXD019060 | Pride
Allgrove syndrome Aladin Aaas Myopodin/synaptopodin-2 Triple-a syndrome Ataxin-2 
ProteomicsMolecular effects of Vitamin C treatment in MSC80 cells, a suitable Schwann cell model
Schwann cells (SCs) are not only decisive to produce the axon-wrapping myelin sheath thus ensuring a proper nerve conduction but also exhibit with trophic function and can direct repair mechanisms of the peripheral nervous system. Consequently, suitable and well-characterized SC in vitro models are ...
ORGANISM(S): Mus musculus (Mouse) 
2018-08-13 | PXD006910 | Pride
Protein cataloguing Msc80 Tmx1 Schwann cells 
TranscriptomicsMolecular anatomy of gene expression responses in stressed hepatocytes
It is well-known that isolation and cultivation of primary hepatocytes causes major gene expression alterations. In the present genome-wide, time resolved study of cultivated human and mouse hepatocytes, we made the observation that expression changes in culture strongly resemble alterations in live...
ORGANISM(S): Mus musculus 
2016-09-28 | E-MTAB-4444 | biostudies-arrayexpress
GenomicsH2A.Z (pht1) ChIP-seq data in 968, Y0036, and swc5-del strains
After finding a QTL hotspot in a fission yeast cross of strains 968xY0036 that was apparently driven by frame shift mutation in swc5 (swc5-fs), we have determined the genome-wide occupancy of the histone variant H2AZ (PhT1). Indeed swc5 has been shown to affect H2AZ occupancy. To test the impact of ...
ORGANISM(S): Schizosaccharomyces pombe 
2014-12-04 | E-MTAB-2650 | biostudies-arrayexpress
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