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TranscriptomicsDifferential Targeting of the E-Cadherin and b-Catenin Complex by Gram-positive Probiotic Lactobacilli Improves Epithelial Barrier Function
The intestinal ecosystem is balanced by dynamic interactions between resident and incoming microbes, the gastrointestinal barrier, and the mucosal immune system. However, in the context of inflammatory bowel diseases (IBD) where the integrity of the gastrointestinal barrier is compromised, resident ...
ORGANISM(S): Homo sapiens 
2012-02-10 | E-MEXP-3445 | biostudies-arrayexpress
ProteomicsProteolytic processing of CD99
The adhesion molecule CD99 is essential for transendothelial migration (TEM) of leukocytes. Here we demonstrate by biochemical and cellular assays that CD99 undergoes ectodomain shedding by the metalloprotease meprin ? and subsequent intramembrane proteolysis by ?-secretase. The cleavage site in CD9...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-29 | MSV000080746 | MassIVE
ProteomicsCell-autonomous hepatocyte-specific GP130 signalling alone is sufficient to trigger robust innate immune response in mice
Members of the IL-6 cytokine family contribute to inflammatory and regenerative processes. Engagement of the signalling receptor subunit gp130 is common to almost all members of the family. In the liver, all major cell types respond to IL-6, making it difficult to delineate cell type-specific effect...
ORGANISM(S): Mus musculus (Mouse) 
2021-08-20 | PXD020744 | Pride
Innate immunity Acute-phase response Il-6 Gp130 
TranscriptomicsThe acclimation of Chlamydomonas reinhardtii to anaerobiosis involves plant and animal strategies
The absence of oxygen (O2) is a stress condition for aerobic organisms and requires extensive acclimation responses. Previously, Chlamydomonas reinhardtii has been used as a reference organism for understanding these acclimation responses. In this work, we use RNA-Seq for a whole genome view of the ...
ORGANISM(S): Chlamydomonas reinhardtii 
2013-07-01 | E-GEOD-42035 | biostudies-arrayexpress
UnknownMassive parallel sequencing and digital gene expression analysis reveals potential mechanisms to overcome therapy resistance in pulmonary neuroendocrine tumors.
Not available
S-EPMC5166524 | biostudies-literature
ProteomicsIonophore 4-Br-A23187 causes copper stress in B. subtilis
Ionophores are small molecules or peptides that transport metal ions across biological membranes. Their transport capabilities are typically characterized in vitro using vesicles and single ion species. It is difficult to infer from these data which effects ionophores have on living cells in a compl...
ORGANISM(S): Bacillus subtilis subsp. subtilis str. 168 
2022-06-08 | PXD028938 | Pride
4-br-a23187 Antibiotic Ionophore Bacillus subtilis Copper 
TranscriptomicsMicroarray analysis of gene expression regulation in LS174T cells transduced with either ERK-dimerization inhibitory peptide or control
Microarray analysis of gene expression regulation in LS174T cells transduced with either ERK-dimerization inhibitory peptide or control.
ORGANISM(S): Homo sapiens 
2020-02-03 | E-MTAB-8111 | biostudies-arrayexpress
TranscriptomicsMicroarray analysis of gene expression regulation in murine hearts treated with an ERK-dimerization inhibitory peptide gene therapy or control after transverse aortic constriction
This study identifies gene expression changes in murine hearts after TAC surgery and in response to gene therapy with ERK-dimerization inhibitory peptide
ORGANISM(S): Mus musculus 
2020-02-03 | E-MTAB-8110 | biostudies-arrayexpress
ProteomicsPhosphodiesterase 10A inhibition improves cortico-basal ganglia function in Huntington’s disease models
Using Huntington’s disease (HD) mouse models that quantitatively replicate the reduction of striatal Phoshodiesterase 10 (PDE10) levels in manifest Huntington’s disease patients, we demonstrate the potential therapeutic benefit of PDE10 inhibition on correcting basal ganglia circuitry deficits thoug...
ORGANISM(S): Mus musculus (Mouse) 
2016-12-02 | PXD005138 | Pride
Huntington's disease  proteomics  phosphoproteomics pde10a striatum 
UnknownMAOA gene hypomethylation in panic disorder-reversibility of an epigenetic risk pattern by psychotherapy.
Not available
S-EPMC4872399 | biostudies-literature
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