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ProteomicsCircadian Regulation of Protein Cargo in Exosomes
The circadian clock controls many aspects of physiology, but it remains undescribed whether extracellular vesicles (including exosomes) involved in cell-cell communications between tissues are regulated in a circadian pattern. We demonstrate a 24 h rhythmic abundance of individual proteins in exosom...
ORGANISM(S): Mus musculus (Mouse) 
2022-05-19 | PXD022393 | Pride
Exosomes Lc-ms Circadian rhythm 
ProteomicsCentral nervous system involvement of acute lymphoblastic leukemia depends on mRNA translation and complement component 3
Central nervous system (CNS) dissemination of B-precursor acute lymphoblastic leukemia (B-ALL) has a poor prognosis and remains a therapeutic challenge with few recent advances in therapy. Leptomeningeal disease is particularly common in the high risk subgroup of KMT2A-rearranged B-ALL (KMT2A-r B-AL...
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD022411 | Pride
Lc-ms Leukemia Lfq 
ProteomicsHigh sensitivity limited material proteomics empowered by data-independent acquisition on linear ion traps
LIT-DIA data from HeLa tryptic peptide dilution series
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2022-06-24 | MSV000089718 | MassIVE
ProteomicsGlobal Identification of the miR-130a targetome in human HSPC Reveals a Novel Role for TBL1XR1 in Hematopoietic Stem Cell Self-Renewal and t(8;21) AML
Gene expression profiling and proteome analysis of normal and malignant hematopoietic stem cells have firmly established the existence of shared core stemness properties. However, the discordance between mRNA and protein signatures underscores an important role for post-transcriptional regulation by...
ORGANISM(S): Homo sapiens (Human) 
2024-06-22 | PXD027331 | Pride
Lc-ms Acute myeloid leukemia Mirna Hematopoiesis 
ProteomicsProteomics Identifies Differences in Fibrotic Potential of Exosomes from Human Tendon and Muscle Fibroblasts
Fibroblasts are the powerhouses responsible for the production and assembly of extracellular matrix. Their activity needs to be tightly controlled especially within the musculoskeletal system, where changes to extracellular matrix composition affect force transmission and mechanical loading that are...
ORGANISM(S): Homo sapiens (Human) 
2021-09-09 | PXD018233 | Pride
Exosomes Human Tendon Fibroblasts Muscle 
ProteomicsA Comparison of Tenocyte Populations from the Core and Periphery of Equine Tendons
Tendon is a highly organized, dense connective tissue that has been demonstrated to have very little turnover. In spite of the low turnover, tendon can grow in response to loading, which may take place primarily at the periphery. Tendon injuries and recurrence of injuries are common in both human an...
ORGANISM(S): Equus caballus (Horse) 
2020-08-24 | PXD019974 | Pride
Shotgun proteomics Tendon Lc-msms 
ProteomicsIntegrative analysis of mesenchymal stromal cell conversion by breast cancer secretomes in blank slate 3D microenvironments
The ability of primary tumour cells to invade and metastasise is responsible for over 90% of cancer patient deaths. During tumour growth and progression, cancer cells secrete factors that recruit and reprogram otherwise healthy cells to facilitate the formation of a favourable tumour microenvironmen...
ORGANISM(S): Homo sapiens (Human) 
2019-05-27 | PXD010467 | Pride
Lc-msms Secretome 
ProteomicsChitin degradation machinery and secondary metabolite profiles in the marine bacterium Pseudoalteromonas rubra S4059
Genome mining of pigmented Pseudoalteromonas has revealed a large potential for production of bioactive compounds, both hydrolytic enzymes and secondary metabolites and the purpose of the present study was to explore this bioactivity potential in a potent antibiotic and enzyme producer, Pseudoaltero...
ORGANISM(S): Pseudoalteromonas rubra 
2021-03-11 | PXD023249 | Pride
Lc-ms Marine bacteria Proteome Secretome 
ProteomicsOrgan specific fibroblast-derived matrix as a tool for understanding breast cancer metastasis
Triple negative breast cancer has an extremely poor prognosis due to lack of available targeted treatments, especially for metastasis. Metastatic sites frequently include the lymph nodes and the lungs, and during the metastatic process, breast cancer cells must come into contact with the extracellul...
ORGANISM(S): Mus musculus (Mouse) 
2022-02-17 | PXD025786 | Pride
Lc-ms Matrix Fibroblasts 
ProteomicsLoss of the NK Motif And AnKyrin Repeat Domain 1 (KANK1) leads to lymphoid compartment dysregulation in mice
The NK Motif And AnKyrin Repeat Domain 1 (KANK1) gene protein plays a role in the control of cytoskeleton formation by regulating actin polymerization. A t(5;9) translocation resulting in a fusion of the platelet-derived growth factor receptor beta gene (PDGFRB) and KANK1 was detected in a patient w...
ORGANISM(S): Mus musculus (Mouse) 
2024-01-26 | PXD045032 | Pride
Mouse Lc-ms 
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