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TranscriptomicsSwitching on antibiotic resistance in Staphylococcus aureus M-bM-^@M-^S Contribution of WalK and VraS histidine kinases in the development of vancomycin and daptomycin resistance
Staphylococcus aureus is a notorious bacterial pathogen that causes a broad range of human diseases, and isolates that are resistant to several antibiotic classes including last resort antibiotics like vancomycin and daptomycin complicate the situation. We characterized S. aureus VC40, a strain that...
ORGANISM(S): Staphylococcus aureus subsp. aureus Mu50 
2014-08-18 | E-GEOD-46887 | biostudies-arrayexpress
TranscriptomicsAnalysis of the CcpA regulon in Staphylococcus aureus
Background The catabolite control protein A (CcpA) is a member of the LacI/GalR family of transcriptional regulators controlling carbon-metabolism pathways in low-GC Gram positive bacteria. It functions as a catabolite repressor or activator, allowing the bacteria to utilize the preferred carbon sou...
ORGANISM(S): Staphylococcus aureus subsp. aureus str. Newman 
2010-06-24 | E-GEOD-12614 | biostudies-arrayexpress
TranscriptomicsCodY in Staphylococcus aureus: regulatory link between metabolism and virulence gene expression
CodY is a conserved regulator in gram-positive organisms described to repress metabolic genes mainly involved in nitrogen metabolism but also to control the expression of virulence genes in pathogens. We constructed codY gene-replacement mutants in three unrelated S. aureus strains (Newman, UAMS-1, ...
ORGANISM(S): Staphylococcus aureus subsp. aureus USA300 
2008-11-06 | E-GEOD-12340 | biostudies-arrayexpress
TranscriptomicsR. conorii transcriptional response within inoculation eschar battlefield
Rickettsia conorii, the causative agent of the MSF is transmitted to humans by the bite of infected ticks Rhipicephalus sanguineus. The skin thus constitutes an important barrier for the entry and propagation of R. conorii. Given this, analysis of the survival strategies used by the bacterium within...
ORGANISM(S): Rickettsia conorii 
2008-11-06 | E-GEOD-12130 | biostudies-arrayexpress
TranscriptomicsThe stringent response of Staphylococcus aureus and its impact on survival after phagocytosis through the induction of intracellular PSMs expression
The stringent response is initiated by rapid (p)ppGpp synthesis, which leads to a profound reprogramming of gene expression in most bacteria. The stringent phenotype seems to be species specific and may be mediated by fundamentally different molecular mechanisms. In Staphylococcus aureus, (p)ppGpp s...
ORGANISM(S): Staphylococcus aureus 
2013-04-05 | E-GEOD-45617 | biostudies-arrayexpress
TranscriptomicsM-OM-^CB-dependent yabJ-spoVG operon involved in regulation of extracellular nuclease, lipase and protease expression in Staphylococcus aureus
The alternative sigma factor M-OM-^CB of Staphylococcus aureus is involved in the coordination of the general stress response, expression of virulence determinants and modulation of antibiotic resistance levels. It controls a large regulon, either directly by recognizing conserved M-OM-^CB promoter ...
ORGANISM(S): Staphylococcus aureus 
2011-11-23 | E-GEOD-30115 | biostudies-arrayexpress
TranscriptomicsMode of action studies of the novel bisquaternary bisnaphthalimide MT02 against Staphylococcus aureus
Screening of various bisquaternary bisnaphthalimides against a variety of human pathogens revealed one compound, designated MT02, with strong inhibitory effects against gram-positive bacteria. The minimal inhibitory concentrations ranged from 0.31 µg/ml against community-acquired methicillin resista...
ORGANISM(S): Staphylococcus aureus 
2011-01-04 | E-GEOD-23077 | biostudies-arrayexpress
TranscriptomicsGdpS contributes to Staphylococcus aureus biofilm formation by regulation of eDNA release
In Staphylococcus aureus, the role of the GGDEF domain containing protein GdpS remains poorly understood. Previous studies reported that gdpS mutant strains had decreased biofilm formation due to changes in icaADBC expression that were independent of cyclic-di-GMP levels. We deleted gdpS in three un...
ORGANISM(S): Staphylococcus aureus 
2014-06-30 | E-GEOD-48656 | biostudies-arrayexpress
TranscriptomicsGlobal analysis of the Staphylococcus aureus response to mupirocin
In the present study we analyzed the response of S. aureus to mupirocin, the drug of choice for nasal decolonization of S. aureus. Mupirocin selectively inhibits the bacterial isoleucyl-tRNA synthetase (IleRSs) leading to the accumulation of uncharged isoleucyl-tRNA and hence (p)ppGpp. The latter is...
ORGANISM(S): Staphylococcus aureus 
2012-01-23 | E-GEOD-30743 | biostudies-arrayexpress
TranscriptomicsA search for small noncoding RNAs in Staphylococcus aureus reveals a conserved sequence motif for regulation.
Analysis of the intergenic regions of Staphylococcus aureus by bioinformatics predicted multiple regulatory regions. From this analysis, we also characterized 11 novel noncoding RNAs (RsaA-K) that are expressed in several S. aureus strains under different experimental conditions. Many of them accumu...
ORGANISM(S): Staphylococcus aureus 
2010-05-18 | E-GEOD-17135 | biostudies-arrayexpress
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