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ProteomicsAgonist-selective NOP receptor phosphorylation correlates in vitro and in vivo and reveals differential post-activation signaling by chemically diverse agonists
Agonists for the nociceptin/orphanin FQ opioid peptide NOP receptor, a member of the opioid receptor family, are under active investigation as novel analgesics, but their modes of signaling are less well characterized than those for other members of the opioid receptor family. Therefore, we investig...
ORGANISM(S): Mus musculus (Mouse) 
2020-05-26 | PXD012908 | Pride
Brain Opioid receptor family Mouse Biological Pharmacology Post-translational modification Nanolc-ms/ms cid/etd Phosphorylation 
ProteomicsHA-MOP knockin mice express the canonical µ-opioid receptor but lack detectable splice variants
G protein-coupled receptors (GPCRs) are notoriously difficult to detect in native tissues. In an effort to resolve this problem, we have developed a novel mouse model by fusing the hemagglutinin (HA)-epitope tag sequence to the amino-terminus of the µ-opioid receptor (MOP). Although HA-MOP knock-in ...
ORGANISM(S): Mus musculus (Mouse) 
2022-12-07 | PXD027825 | Pride
Brain Mouse Pharmacology Mop splice variants Opioid receptor family Nanolc-ms/ms cid/etd Phosphorylation 
UnknownYB-1 Is a Novel Target for the Inhibition of α-Adrenergic-Induced Hypertrophy.
Not available
S-EPMC10778708 | biostudies-literature
UnknownAssociations of cortical thickness and cognition in patients with schizophrenia and healthy controls.
Not available
S-EPMC3446215 | biostudies-literature
UnknownLong-lasting improvements in liver fat and metabolism despite body weight regain after dietary weight loss.
Not available
S-EPMC3816862 | biostudies-literature
UnknownChemotherapy plus Rituximab versus chemotherapy alone for B-cell non-Hodgkin's lymphoma.
Not available
S-EPMC9017066 | biostudies-literature
ProteomicsProteomic analysis of a novel iPSC-derived 3D brain tissue model (3BTM) of Alzheimer’s disease
Stem-cell-based in vitro models offer promising potential to elucidate pathomechanisms underlying neurological diseases such as Alzheimer’s disease. However, harnessing this potential is currently impaired by low reproducibility, maturity, and cell-type diversity of models and lack of AD-relevant pa...
ORGANISM(S): Homo sapiens (Human) 
2026-02-23 | PXD055254 | Pride
Dia Ipsc Label-free Human Cortical tissue model 
ProteomicsProteomic analysis of a novel iPSC-derived 3D brain tissue model (3BTM) of Alzheimer’s disease
Stem-cell-based in vitro models offer promising potential to elucidate pathomechanisms underlying neurological diseases such as Alzheimer’s disease. However, harnessing this potential is currently impaired by low reproducibility, maturity, and cell-type diversity of models and lack of AD-relevant pa...
ORGANISM(S): Homo sapiens (Human) 
2026-02-23 | PXD071849 | Pride
3d brain tissue model Alzheimer’s disease 3btm Brain Ipsc 
TranscriptomicsExon array analysis of two human cell lines (HEK293T Ramos B cell)
In order to compare previously generated transcriptome data by second generation sequencing (Sultan et al. Science 2008), we interrogated the human Affymetrix exon chips 1.0ST using the same source of material. Two biological replicates from HEK293T and B cell lines were hybridized on the human A...
ORGANISM(S): Homo sapiens 
2010-05-15 | E-GEOD-13474 | biostudies-arrayexpress
ProteomicsAssessing inter-line reproducibility of a novel iPSC-derived 3D brain tissue model (3BTM) and comparison to 2D co-cultures
Stem-cell-based in vitro models offer promising potential to elucidate human brain cell functions and interactions under healthy conditions and in disease states. However, harnessing this potential is currently impaired by low reproducibility, maturity, and cell-type diversity of models. Therefore, ...
ORGANISM(S): Homo sapiens (Human) 
2026-02-23 | PXD069984 | Pride
3d brain tissue model 3btm Brain Ipsc 
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