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TranscriptomicsIdentification of STAT5 target genes in human CB HSC, CMP, GMP and MEP
CB CD34+ cells were isolated by Miltenyi miniMACS column. Cells were prestimulated in HPGM with 100 ng/ml KITL, FLT#L and TPO for 48 hrs. Cells were transduced with control MiNR1 or STAT5A-ER in three rounds over 48 hrs. Hematopoietic stem cells (HSCs), common myeloid progenitors (CMPs), granulocyte...
ORGANISM(S): Homo sapiens 
2011-01-22 | E-GEOD-26775 | biostudies-arrayexpress
TranscriptomicsIdentification of hypoxia target genes in human CB CD34+ cells
Although it has been shown that HIF1 and 2 fulfill essential roles within the hematopoietic system and in the regulation of HSC fate, little is currently known about the specific mechanisms that are involved. We identified transcriptome changes induced by hypoxia, constitutively active HIF1(P402/564...
ORGANISM(S): Homo sapiens 
2014-03-01 | E-GEOD-54661 | biostudies-arrayexpress
TranscriptomicsIdentification of HIF1 and HIF2 target genes in human CB CD34+ cells
Although it has been shown that HIF1 and 2 fulfill essential roles within the hematopoietic system and in the regulation of HSC fate, little is currently known about the specific mechanisms that are involved. We identified transcriptome changes induced by hypoxia, constitutively active HIF1(P402/564...
ORGANISM(S): Homo sapiens 
2014-03-01 | E-GEOD-54662 | biostudies-arrayexpress
TranscriptomicsIdentification of hypoxia, HIF1 and HIF2 target genes in human CB CD34+ cells
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2014-03-01 | E-GEOD-54663 | biostudies-arrayexpress
ProteomicsLabel-free quantitative proteome of AML CD34+ and mobilized PB CD34+ cells
The label-free quantitative proteome was generated for 42 primary AML patient samples enriched for CD34+ cells (or mononuclear cells in the case of NPMcyt sameples) and as controls 6 mobilized peripheral blood CD34+ cells were included. Furthermore, 6 AML cell lines were included, and also primary m...
ORGANISM(S): Homo sapiens (Human) 
2022-03-15 | PXD030463 | Pride
Acute myeloid leukemia Leukemic stem/progenitor cells 
ProteomicsLabel-free quantitative proteome of CD34+ or CKIT+ AML cells and mobilized PB CD34+ cells
The label-free quantitative proteome was generated for 30 primary AML patient samples enriched for CD34+ cells or CKIT+ cells in the case of NPMcyt samples. As controls 3 mobilized peripheral blood CD34+ cells were included.
ORGANISM(S): Homo sapiens (Human) 
2025-01-07 | PXD030487 | Pride
Acute myeloid leukemia Leukemic stem/progenitor cells 
ProteomicsThe USP7-TRIM27 axis as part of non-canonical PRC1.1 is a druggable target in leukemia
In an attempt to unravel the functionality and targettability of the non-canonical PRC1.1 Polycomb complex in human leukemogenesis, we dissected the subunit composition of the PRC1.1 complex and show that USP7 and TRIM27 are integral components. USP7 interactome analyses show that PRC1.1 is the pred...
ORGANISM(S): Homo sapiens (Human) 
2021-06-14 | PXD018365 | Pride
Trim27 Leukemia Prc1.1 Polycomb Usp7 
UnknownRUNX1 mutations enhance self-renewal and block granulocytic differentiation in human in vitro models and primary AMLs.
Not available
S-EPMC6373749 | biostudies-literature
UnknownInhibition of autophagy as a treatment strategy for p53 wild-type acute myeloid leukemia.
Not available
S-EPMC5550863 | biostudies-literature
UnknownMitochondrial Dysfunction in Human Leukemic Stem/Progenitor Cells upon Loss of RAC2.
Not available
S-EPMC4446344 | biostudies-literature
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