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ProteomicsLabel-free quantitative proteome of AML CD34+ and mobilized PB CD34+ cells
The label-free quantitative proteome was generated for 42 primary AML patient samples enriched for CD34+ cells (or mononuclear cells in the case of NPMcyt sameples) and as controls 6 mobilized peripheral blood CD34+ cells were included. Furthermore, 6 AML cell lines were included, and also primary m...
ORGANISM(S): Homo sapiens (Human) 
2022-03-15 | PXD030463 | Pride
Acute myeloid leukemia Leukemic stem/progenitor cells 
ProteomicsLabel-free quantitative proteome of CD34+ or CKIT+ AML cells and mobilized PB CD34+ cells
The label-free quantitative proteome was generated for 30 primary AML patient samples enriched for CD34+ cells or CKIT+ cells in the case of NPMcyt samples. As controls 3 mobilized peripheral blood CD34+ cells were included.
ORGANISM(S): Homo sapiens (Human) 
2025-01-07 | PXD030487 | Pride
Acute myeloid leukemia Leukemic stem/progenitor cells 
ProteomicsThe USP7-TRIM27 axis as part of non-canonical PRC1.1 is a druggable target in leukemia
In an attempt to unravel the functionality and targettability of the non-canonical PRC1.1 Polycomb complex in human leukemogenesis, we dissected the subunit composition of the PRC1.1 complex and show that USP7 and TRIM27 are integral components. USP7 interactome analyses show that PRC1.1 is the pred...
ORGANISM(S): Homo sapiens (Human) 
2021-06-14 | PXD018365 | Pride
Trim27 Leukemia Prc1.1 Polycomb Usp7 
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