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MetabolomicsSerum LC-MS metabolomics profiling during musk secretion in captive forest musk deer (Moschus berezovskii)
This study investigates serum metabolomic changes associated with musk secretion in captive male forest musk deer (Moschus berezovskii). Paired serum samples were collected before secretion and during secretion and analyzed using LC-MS in both positive and negative ion modes. The study includes biol...
2026-04-23 | MTBLS14280 | MetaboLights
MetabolomicsA neurotoxic cellular stress response linked to dark microglia and toxic lipid secretion

Microglia, the brain’s primary resident immune cells, can assume various phenotypes with diverse functional outcomes on brain homeostasis. In Alzheimer’s disease (AD), where microglia are a leading causal cell type, the identity of microglia subsets that drive neurodegeneration remains unresolved...

2024-12-20 | MTBLS11942 | MetaboLights
MetabolomicsCitrate serves as a signal molecule to modulate carbon metabolism and iron homeostasis in Staphylococcus aureus

Pathogenic bacteria's metabolic adaptation for survival and proliferation within hosts is a crucial aspect of bacterial pathogenesis. Here, we demonstrate that citrate, the first intermediate of the tricarboxylic acid (TCA) cycle, plays a key role as a regulator of gene expression in Staphylococc...

2024-04-26 | MTBLS4276 | MetaboLights
TranscriptomicsGlobal impact of Salmonella type III secretion effector SteA on host cells
Salmonella enterica is a Gram-negative bacterium that causes gastroenteritis, bacteremia and typhoid fever in several animal species including humans. Its virulence is greatly dependent on two type III secretion systems (T3SSs), encoded in pathogenicity islands 1 (SPI1) and 2 (SPI2), respectively. T...
ORGANISM(S): Homo sapiens 
2014-05-28 | E-GEOD-51043 | biostudies-arrayexpress
TranscriptomicsSecretion stress caused by overexpression of heterologous α-amylase in Bacillus subtilis
Transcriptome analysis was used to investigate the global stress response of the Gram-positive bacterium Bacillus subtilis caused by overproduction of the well-secreted AmyQ α-amylase from Bacillus amyloliquefaciens. Analyses of the control and overproducing strains were carried out at the end of ex...
ORGANISM(S): Bacillus subtilis subsp. subtilis str. 168 
2007-10-01 | E-GEOD-8014 | biostudies-arrayexpress
GenomicsThe PhoP-dependent ncRNA Mcr7 modulates the TAT secretion system in Mycobacterium tuberculosis [ChIP-Seq]
The PhoPR two-component system is essential for virulence in Mycobacterium tuberculosis where it controls expression of approximately 2% of the genes, including those for the ESX-1 secretion apparatus, a major virulence determinant. Mutations in phoP lead to compromised production of pathogen-specif...
ORGANISM(S): Mycobacterium tuberculosis H37Rv 
2014-06-02 | E-GEOD-54239 | biostudies-arrayexpress
TranscriptomicsThe PhoP-dependent ncRNA Mcr7 modulates the TAT secretion system in Mycobacterium tuberculosis [RNA-Seq]
The PhoPR two-component system is essential for virulence in Mycobacterium tuberculosis where it controls expression of approximately 2% of the genes, including those for the ESX-1 secretion apparatus, a major virulence determinant. Mutations in phoP lead to compromised production of pathogen-specif...
ORGANISM(S): Mycobacterium tuberculosis H37Rv 
2014-06-02 | E-GEOD-54240 | biostudies-arrayexpress
ProteomicsSpecialized shuttle proteins recognize and target type IX secretion effectors
Members of the phylum Bacteroidota utilize the type IX secretion system (T9SS) to transport diverse substrates into the environment or onto their surface. T9SS substrates feature a Sec-dependent signal peptide for export to the periplasm and a conserved C-terminal domain (CTD), recognized by the T9S...
ORGANISM(S): Flavobacterium johnsoniae 
2025-09-03 | PXD065655 | Pride
Type ix secretion Lc-msms Secretion signal Bacteroidota Flavobacterium 
TranscriptomicsGene expression of soybean roots inoculated with wild-type and type III secretion mutant strains of Bradyrhizobium elkanii
To dissect differences in gene expression profile of soybean roots inoculated with wild-type and type III secretion mutant rhizobia, we have employed microarray analysis. Seeds of soybeans (Glycine max L. cv. Enrei and its non-nodulating line En1282) were surface-sterilized and germinated at 25 M-BM...
ORGANISM(S): Glycine max 
2013-09-17 | E-GEOD-38520 | biostudies-arrayexpress
ProteomicsHigher induction temperatures and the native secretion signal peptide promote rye prolamin 75k γ-secalin production in Komagataella phaffii
Background: Gluten proteins from wheat, rye, and barley play a substantial role in human nutrition. At the same time, they can trigger several different immune reactions. This, together with their influence on the quality of grain products and their emerging role as biomaterials, makes them an inter...
ORGANISM(S): Komagataella phaffii Secale cereale 
2025-09-09 | PXD062119 | Pride
Secretion signal peptides Prolamin Komagataella phaffii Erad Secale cereale Upr Gluten 
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