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The human seminal plasma is a potential source of biomarkers for male reproductive disorders. A tissue-profiling analysis of the main organs participating in the secretion of this body fluid was conducted to identify tissue-specific genes along the male reproductive tract. Total RNA from non patholo...
ORGANISM(S): Homo sapiens 
BACKGROUND: Prostate cancer is the most frequently diagnosed cancer among men in the United States. In contrast, cancer of the seminal vesicle is exceedingly rare, despite that the prostate and seminal vesicle share similar histology, secretory function, androgen dependency, blood supply, and (in p...
ORGANISM(S): Homo sapiens 
We performed proteomics analysis of Yorkshire Seminal plasma extracellular vesicles(SPEVs) with high or low sperm motility to investigate specific biomarker affecting sperm motility.Twelve Yorkshire boars with extremely high (H) or low (L) sperm motility were selected, with six individuals in each g...
ORGANISM(S): Sus scrofa domesticus (domestic pig) 
2025-05-06 | PXD050238 | Pride
Extracellular Vesicles (EVs) derived from seminal plasma have achieved considerable attention due to their potential role in male reproductive physiology and pathology. In this study, we employed a comprehensive proteomic and transcriptomic approach to investigate the molecular signatures of EVs iso...
ORGANISM(S): Homo sapiens (Human) 
2025-06-30 | PXD051361 | Pride
This project comprises 12 proteomic samples analyzed using data-independent acquisition (DIA, also known as SWATH). Proteins were isolated from extracellular vesicles enriched from the seminal plasma of boar AI semen doses, including samples from high-fertility males (n = 6) and reduced-fertility ma...
ORGANISM(S): Sus scrofa domesticus (domestic pig) 
2026-06-10 | PXD079300 | Pride
Quantitative proteomic studies are contributing greatly to our understanding of the spermatozoon through the provision of detailed information on the proteins spermatozoa acquire and shed in the acquisition of fertility. Extracellular vesicles (EVs) are thought to aid in the delivery of proteins to ...
ORGANISM(S): Ovis aries 
2020-05-08 | PXD017537 | Pride
The seminal vesicles are an integral part of the male accessory gland system, and are responsible for producing a complex array of bioactive moieties that support gamete function and promote reproductive success. However, despite their physiological significance, the biology of the seminal vesicles ...
ORGANISM(S): Mus musculus (Mouse) 
2021-05-31 | PXD021998 | Pride
Predicting male fertility remains a major challenge in livestock industry. Seminal plasma contains a heterogeneous population of extracellular vesicles (sEVs) that are involved in the regulation of sperm functionality and may therefore be involved in male fertility. The aim of this study was to eval...
ORGANISM(S): Sus scrofa domesticus (domestic pig) 
2026-02-02 | PXD055970 | Pride
Ejaculates contain a diverse mixture of sperm and seminal fluid proteins, the combination of which is crucial to male reproductive success under competitive conditions. Males should therefore tailor the production of different ejaculate components according to their social environment, with particul...
ORGANISM(S): Mus musculus (Mouse) 
2015-10-01 | PXD002900 | Pride
Extracellular Vesicles (EVs) derived from seminal plasma have achieved considerable attention due to their potential role in male reproductive physiology and pathology. In this study, we employed a comprehensive proteomic and transcriptomic approach to investigate the molecular signatures of EVs iso...
ORGANISM(S): Homo sapiens (Human) 
2025-06-30 | PXD051390 | Pride
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