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ProteomicsA Survey of Serine Hydrolase Activity in Mycobacterium tuberculosis
Changes in Serine Hydrolase Activity Associated with Mycobacterium tuberculosis Replication
ORGANISM(S): Mycobacterium tuberculosis 
2016-02-01 | PXD002763 | Pride
Replication Serine hydrolase 
ProteomicsProtease activity profiling of ovarian clear cell carcinoma
Ovarian clear cell carcinoma (OCCC) is an understudied poor prognosis subtype of ovarian cancer lacking in effective molecularly targeted therapies; efforts to define drivers of OCCC malignancy may lead to new therapeutic targets and approaches. Among potential targets are secreted proteases, enzyme...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2021-05-07 | MSV000087385 | MassIVE
ProteomicsIdentification of a S. aureus virulence factor by activity-based protein profiling (ABPP)
Serine hydrolases play diverse roles in regulating host-pathogen interactions in a number of organisms, yet few have been characterized in the human pathogen Staphylococcus aureus. Here, we describe a chemical proteomic screen that identified 10 previously uncharacterized S. aureus serine hydrolases...
ORGANISM(S): Staphylococcus aureus 
2018-05-17 | PXD009210 | Pride
Abpp S. aureus Serine hydrolase 
ProteomicsActivity-based proteomic profiling (ABPP) employing a serine hydrolase-directed probe to identify changes in activity profiles of lipid hydrolase in lung tumors
Lung tumors, as well as normal tumor-adjacent (NTA) tissue of non-small cell lung cancer (NSCLC) patients, were collected and subjected to labeling with a serine hydrolase-directed activity-based probe (ABP) immediately after excision. Labeling with the serine hydrolase-directed ABP allows for the d...
ORGANISM(S): Homo sapiens (Human) 
2023-11-27 | PXD046934 | Pride
Abpp Lipid hydrolysis Serine hydrolase Nsclc Lipid hydrolase Lung tumor Activity-based proteomic profiling Lipase 
ProteomicsActivity-Based Protein Profiling of Human and Plasmodium Serine Hydrolases and Interrogation of Potential Antimalarial Targets
Malaria remains a global health issue requiring the identification of novel therapeutic targets to combat drug resistance. Metabolic serine hydrolases are druggable enzymes playing essential roles in lipid metabolism. However, very few have been investigated in malaria-causing parasites. Here, we us...
ORGANISM(S): Homo sapiens (Human) Plasmodium falciparum (isolate 3D7) 
2022-10-14 | PXD035891 | Pride
Abp Abpp Plasmodium falciparum Serine hydrolase Malaria Chemical proteomics Fluorophosphonate 
ProteomicsMycobacterium tuberculosis normoxia hypoxia reactivation with ActivX-desthiobiotin FP probe
Lysates of Mycobacterium tuberculosis (H37Rv auxotroph mc(2)6020) grown under various conditions (normoxia, hypoxia, reactivation from hypoxia) probed the serine hydrolase probe with ActivX-desthiobiotin FP.
ORGANISM(S): Mycobacterium Tuberculosis (ncbitaxon:1773) 
2016-10-10 | MSV000080238 | MassIVE
UnknownComparative analysis of the human serine hydrolase OVCA2 to the model serine hydrolase homolog FSH1 from S. cerevisiae.
Not available
S-EPMC7077851 | biostudies-literature
ProteomicsCHEMICAL PROTEOMIC ANALYSIS OF ENDOCANNABINOID HYDROLASE ACTIVITY IN NIEMANN-PICK TYPE C MOUSE BRAIN
The endocannabinoid system is considered to be an endogenous protective system in various neurodegenerative diseases. Niemann-Pick Type C is a neurodegenerative disease in which the role of the endocannabinoid system has not been studied yet. Here, we report the endocannabinoid hydrolase activity in...
ORGANISM(S): Mus musculus (Mouse) 
2018-04-19 | PXD008979 | Pride
Mouse Brain Orbitrap Activity-based protein profiling Niemann-pick type c Synapt 
UnknownLigand binding Pro-miscuity of acylpeptide hydrolase, structural analysis of a detoxifying serine hydrolase.
Not available
S-EPMC12514842 | biostudies-literature
UnknownRBBP9: a tumor-associated serine hydrolase activity required for pancreatic neoplasia.
Not available
S-EPMC2836678 | biostudies-literature
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