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UnknownEpigenome-wide association study of COVID-19 severity with respiratory failure.
Not available
S-EPMC8047083 | biostudies-literature
UnknownEpigenetic profiling linked to multisystem inflammatory syndrome in children (MIS-C): A multicenter, retrospective study.
Not available
S-EPMC9233426 | biostudies-literature
ProteomicsSIRT1 regulates DNA damage signaling through PP4 phosphatase complex
The Sirtuin family of NAD+-dependent enzymes play an important role in the maintenance of genome stability upon stress. Several mammalian Sirtuins have been linked directly or indirectly to the regulation of DNA damage during replication through Homologous recombination (HR). The role of one of them...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2023-06-15 | PXD036905 | Pride
Label free proteomics Pp4 phosphatase complex H2ax Sirt1 Dna damage response 
UnknownUnseen threat: how subclinical atherosclerosis increases mortality risk in patients with type 1 diabetes.
Not available
S-EPMC11488122 | biostudies-literature
ProteomicsInhibition of CBP synergizes with the RNA-dependent mechanisms of azacitidine by limiting protein translation
The nucleotide analogue azacitidine (AZA) interferes with RNA and DNA metabolism and is currently the best treatment option for a subset of patients with high-risk myelodysplastic syndromes. However, only half of treated patients respond and almost all patients that initially respond eventually rela...
ORGANISM(S): Homo sapiens (Human) 
2021-09-22 | PXD021738 | Pride
Hypomethylating agents  azacitidine  epigenetic regulation  lysine acetyl tranferase inhibitors  creb binding protein / cbp / p300  shrna screen  protein synthesis Clonal hematopoietic disorders Myelodysplastic syndromes  secondary acute myeloid leukemia 
ProteomicsExploring Diverse Clinical Presentations in COVID-19 through Circulating Extracellular Vesicle Proteomics Analysis
Extracellular vesicles (EVs) released by virus-infected cells are susceptible to incorporate viral peptides. Here, we hypothesized that the molecular characterization of EVs obtained from COVID-19 patients will reveal novel immunogenic viral peptides. Blood from COVID-19 patients with severe (G1), m...
ORGANISM(S): Homo sapiens (Human) Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) 
2024-09-25 | PXD041931 | Pride
Proteomics profiling Covid-19 patients Clinical data Ganglioside-capture(siglec-1) Antibody response Extracellular vesicles Size-exclusion chromatography(sec) Tandem mass tag(tmt) Immunocapture(cd9) 
UnknownA Novel Family of Lysosomotropic Tetracyclic Compounds for Treating Leukemia.
Not available
S-EPMC10047683 | biostudies-literature
ProteomicsIdentification of auto mono-ADP-ribosylation sites on SIRT6 and SIRT7
The aim of this project was to identify the auto mono-ADP-ribosylation sites on SIRT6 and SIRT7 to study the effect of the point mutations S56A and N189A respectively on their ADP-ribosylation activity. In addition, the mono-ADP-ribosylation pattern of SIRT7 was obtained in cells under different str...
ORGANISM(S): Homo sapiens (Human) 
2021-04-19 | PXD018344 | Pride
Sirtuins  sirt7  adp-ribosylation  macroh2a  glucose starvation  chromatin  calorie restriction  aging  orbitrap lumos  orbitrap eclipse 
ProteomicsDiscovery, characterization and quantification of bioactive peptides contained in Palbio porcine intestinal mucosa hy-drolysate products.
Porcine intestinal mucosa hydrolysates (PIMH) are a by-product of heparin production obtained through a specific enzymatic hydrolysis process which can theoretically generate bioactive pep-tides (BAPs). This study aimed to identify, characterize and quantify BAPs in two Palbio products manufactured ...
ORGANISM(S): Sus scrofa (Pig) 
2025-08-04 | PXD063531 | Pride
Bioactive peptides  antimicrobial peptides  sustainable processing  porcine intestinal mucosa hydrolysate  porcine digestible peptides  bio-compound valorization  animal by-products 
ProteomicsEvaluation of tumor interstitial fluid-extraction methods for proteome analysis: comparison of biopsy elution versus centrifugation
The analysis of Tumor Interstitial Fluid (TIF) composition is a valuable procedure to identify anti-metastatic targets, and different laboratories have set up techniques for TIF isolation and proteomic analyses. However, those methods had never been compared in samples from the same tumor and patien...
ORGANISM(S): Homo sapiens (Human) 
2020-05-06 | PXD016261 | Pride
Cutaneous squamous cell carcinoma Skin cancer Tumor interstitial fluid Spin Proteome Centrifugation Elution 
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