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MetabolomicsDissection of two routes to naïve pluripotency using different kinase inhibitors
Embryonic stem cells (ESCs) can be maintained in the naïve state through inhibition of Mek1/2 and Gsk3 (2i). A relevant effect of 2i is the inhibition of Cdk8/19, which are negative regulators of the Mediator complex, responsible for the activity of enhancers. Inhibition of Cdk8/19 (Cdk8/19i) stimul...
2021-02-10 | MTBLS301 | MetaboLights
TranscriptomicsTranscriptional profiles by deep sequencing (RNA-seq) of in vivo-generated mouse iPSCs, in vitro-generated mouse iPSCs, and mouse ESCs
We have generated M-bM-^@M-^\reprogrammableM-bM-^@M-^] transgenic mice that ubiquitously express the four Yamanaka factors in an inducible manner. Transitory induction of the transgene results in multiple teratomas emerging from a variety of organs, thus indicating that full reprogramming into iPSCs...
ORGANISM(S): Mus musculus 
2013-09-12 | E-GEOD-48364 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of cell lines produced from premalignant tumors with induced sensence
Oncogene-induced senescence is a cellular response that may be crucial for protection against cancer development, but its investigation has so far been restricted to cultured cells that have been manipulated to overexpress an oncogene. Here we analyse tumours initiated by an endogenous oncogene, ras...
ORGANISM(S): Homo sapiens 
2007-10-02 | E-GEOD-2487 | biostudies-arrayexpress
UnknownCardiac Myxoma Associated With Supraventricular Tachycardia as an Unusual Cause of Unilateral Pulmonary Edema.
Not available
S-EPMC11775795 | biostudies-literature
ProteomicsInduction of senescence renders cancer cells highly immunogenic
Cellular senescence is a stress response that activates innate immunity. However, the interplay between senescent cells and the adaptive immune system remains largely unexplored. Here, we show that senescent cells display enhanced MHC class I (MHC-I) antigen processing and presentation. Immunization...
ORGANISM(S): Mus musculus (Mouse) 
2022-11-09 | PXD034059 | Pride
Senescence Anti-tumor immunity Cancer vaccines Antigen presentation Immunogenicity 
UnknownPostepizootic Persistence of Asymptomatic Mycoplasma conjunctivae Infection in Iberian Ibex.
Not available
S-EPMC5514678 | biostudies-literature
ProteomicsSuperior metabolic improvement of polycystic ovary syndrome traits after GLP1-based multi-agonist therapy
Polycystic ovary syndrome (PCOS) is a heterogeneous condition, of polyhedric pathogenesis and clinical presentation, defined by oligo-/anovulation, hyperandrogenism and/or polycystic ovaries. Metabolic complications are highly common also in patients suffering PCOS, including obesity, insulin resist...
ORGANISM(S): Mus musculus (Mouse) 
2024-10-02 | PXD044134 | Pride
Pcos Glp1 Glp1/gip Glp1/gip/glucagon Glp1/e 
UnknownA Scalable Synthesis of Ag Nanoporous Film As an Efficient SERS-Substrates for Sensitive Detection of Nanoplastics.
Not available
S-EPMC11340027 | biostudies-literature
UnknownMorin improves learning and memory in healthy adult mice.
Not available
S-EPMC10897355 | biostudies-literature
TranscriptomicsThe stress kinase MKK7 couples oncogenic stress to p53 stability and tumor suppression
Transcriptional profiling of control and MKK7-deficient primary mouse pneumocytes after oncogenic KRasG12 induction Two-condition experiment, MKK7 proficient vs. MKK7 deficient pneumocytes. 3 Biological replicates: 3 control, 3 knock out, independently grown and harvested. 3 technical replicates p...
ORGANISM(S): Mus musculus 
2011-01-21 | E-GEOD-26763 | biostudies-arrayexpress
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