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ProteomicsProteome dynamics during differentiation of SGBS adipocytes
Here, we identified temporal dynamics in the proteome during adipocyte differentiation of the human SGBS cells, applying untargeted proteomics. Samples were taken at initiation of differentiation, at an intermediate and terminal time point.
ORGANISM(S): Homo sapiens (Human) 
2024-06-13 | PXD045767 | Pride
Adipogenesis Adipocytes Proteome Temporal dynamics Sgbs 
ProteomicsAcetylome dynamics during differentiation of SGBS adipocytes
Here, we identified temporal dynamics of the acetylome during adipocyte differentiation in human SGBS cells, applying untargeted proteomics in combination with immunoaffinity purification of acetylated peptides. Samples were taken at initiation of differentiation, at an intermediate and terminal tim...
ORGANISM(S): Homo sapiens (Human) 
2024-06-13 | PXD045768 | Pride
Adipogenesis Acetylome Adipocytes Temporal dynamics Sgbs 
ProteomicsPhosphoproteome dynamics during differentiation of SGBS adipocytes
Here, we identified temporal dynamics of the phosphoproteome during adipocyte differentiation in the human SGBS cells, applying untargeted proteomics in combination with enrichment strategies for phosphorylated peptides. Samples were taken at initiation of differentiation, at an intermediate and ter...
ORGANISM(S): Homo sapiens (Human) 
2024-06-13 | PXD045770 | Pride
Adipogenesis Adipocytes Phosphoproteome Temporal dynamics Sgbs 
ProteomicsEffects of plasticizers on adult human adipocytes (SGBS) using global proteomics
SGBS cells were used as a model system to investigate the cellular mode of action of a variety of plasticizers in human adipocytes. In brief, cells were cultured at 5% CO2 and 37°C in 95% humidity. Cells of generation 40 and passage 3 after thawing were grown to confluence with DMEM/F12 containing 3...
ORGANISM(S): Homo sapiens (Human) 
2022-06-20 | PXD030843 | Pride
Xenobiotics Tmt Adipocytes Global proteomics Untargeted proteomics Sgbs 
TranscriptomicsExpression data from human SGBS adipocytes under hypoxic conditions
Hypoxia in adipose tissue is suggested to be involved in the development of a chronic mild inflammation, which in obesity can further lead to insulin-resistance. The effect of hypoxia on gene expression in adipocytes seems to play a central role in this inflammatory response observed in obesity. How...
ORGANISM(S): Homo sapiens 
2011-04-14 | E-GEOD-28603 | biostudies-arrayexpress
TranscriptomicsOpen chromatin profiling (ATAC-seq) of SGBS human preadipocytes (days 0, 2, 8 and 16 of differentiation to adipocytes) and iPSC-derived hypothalamic neurons (days 12, 16 and 27 of differentiation)
Human SGBS preadipocytes were differentiated into adipocytes, and human iPSCs were differentiated into hypothalamic neurons. Cells were collected for ATAC-seq at several differentiation stages. The differentiations were performed in one biological replicate, with two technical replicates (different ...
ORGANISM(S): Homo sapiens 
2021-05-22 | E-MTAB-10462 | biostudies-arrayexpress
TranscriptomicsGene expression profiling (RNA-seq) of SGBS human preadipocytes (days 0, 2, 8 and 16 of differentiation to adipocytes) and iPSC-derived hypothalamic neurons (days 12, 16 and 27 of differentiation)
Human SGBS preadipocytes were differentiated into adipocytes, and human iPSCs were differentiated into hypothalamic neurons. Cells were collected for RNA-seq at several differentiation stages. The differentiations were performed in one biological replicate, with three technical replicates (different...
ORGANISM(S): Homo sapiens 
2021-05-22 | E-MTAB-10461 | biostudies-arrayexpress
TranscriptomicsIn situ promoter capture Hi-C data of differentiated SGBS human preadipocytes (days 0, 2, 8 and 16 of differentiation to adipocytes) and iPSC-derived hypothalamic neurons (days 12, 16 and 27 of differentiation)
Human SGBS preadipocytes were differentiated into adipocytes, and human iPSCs were differentiated into hypothalamic neurons. Cells were collected for in situ promoter capture Hi-C [PMID: 29988018] at several differentiation stages. The differentiations were performed in one biological replicate, wit...
ORGANISM(S): Homo sapiens 
2021-05-29 | E-MTAB-10488 | biostudies-arrayexpress
ProteomicsEffects of MINCH exposure on the acetylome of differentiating human SGBS adipocytes
Here, we evaluated the molecular effects of MINCH exposure, as primary metabolite of the DEHP substitute DINCH, on the acetylome profiles of differentiating SGBS adipocytes. This study includes data on rosiglitazone differentiated controls, 10 µM MINCH exposure, and exposure to the selective PPAR in...
ORGANISM(S): Homo sapiens (Human) 
2025-08-05 | PXD059390 | Pride
Acetylome Adipogenesis Dinch Adipocytes Minch Sgbs Gw9662 
ProteomicsEffects of MINCH exposure on the phosphoproteome of differentiating human SGBS adipocytes
Here, we evaluated the molecular effects of MINCH exposure, as primary metabolite of the DEHP substitute DINCH, on the phosphoproteome profiles of differentiating SGBS adipocytes. This study includes data on rosiglitazone differentiated controls, 10 µM MINCH exposure, and exposure to the selective P...
ORGANISM(S): Homo sapiens (Human) 
2025-08-05 | PXD059416 | Pride
Adipogenesis Phosphoproteome Dinch Adipocytes Minch Sgbs Gw9662 
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