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ProteomicsProteome characterization of BALF extracellular vesicles in Idiopathic Pulmonary Fibrosis: unveiling undercover molecular pathways.
In the longtime challenge of identifying specific, easily-detectable and reliable biomarkers of interstitial lung diseases (ILDs), alternative biofluids, such as bronchoalveolar lavage fluid (BALF), have been extensively studied. In particular, BALF proteomics is gaining momentum and providing inter...
ORGANISM(S): Homo sapiens (Human) 
2021-08-06 | PXD025590 | Pride
Balf  extracellular vesicles  ipf  fibrosis  shotgun  proteomics 
ProteomicsCharacterization of extracellular vesicles in human seminal plasma: a multiomic analysis
Extracellular Vesicles (EVs) derived from seminal plasma have achieved considerable attention due to their potential role in male reproductive physiology and pathology. In this study, we employed a comprehensive proteomic and transcriptomic approach to investigate the molecular signatures of EVs iso...
ORGANISM(S): Homo sapiens (Human) 
2025-06-30 | PXD051390 | Pride
Extracellular vesicles  seminal plasma  multi-omics  proteomics  transcriptomics 
ProteomicsCharacterization of extracellular vesicles in human seminal plasma: a multiomic analysis
Extracellular Vesicles (EVs) derived from seminal plasma have achieved considerable attention due to their potential role in male reproductive physiology and pathology. In this study, we employed a comprehensive proteomic and transcriptomic approach to investigate the molecular signatures of EVs iso...
ORGANISM(S): Homo sapiens (Human) 
2025-06-30 | PXD051361 | Pride
Extracellular vesicles  seminal plasma  multi-omics  proteomics  transcriptomics 
ProteomicsProteomics reveals how the tardigrade damage suppressor protein teaches transfected human cells to survive UV-C stress
The genome sequencing of the tardigrade Ramazzottius varieornatus revealed a unique nucleo-some-binding protein, named Damage Suppressor (Dsup), which resulted to be crucial for the extraordinary abilities of tardigrades in surviving extreme stresses, such as UV. Evidence in Dsup transfected human c...
ORGANISM(S): Homo sapiens (Human) 
2023-07-31 | PXD037439 | Pride
Proteomics Stress granules Dsup Telomere lenght Dna damage response 
ProteomicsHypothyroidism symptoms in LT4-euthyroid thyroidectomized patients reflect an alteration of the serum proteome
In patients undergoing thyroidectomy one of the goals of post-surgical follow-up is the correct maintenance of thyroid hormone (TH) levels by replacement therapy with levo-thyroxine (LT4). Nevertheless, some patients complain of symptoms of hypothyroidism (memory loss, weight gain, fatigue, depressi...
ORGANISM(S): Homo sapiens (Human) 
2022-04-04 | PXD028378 | Pride
Quality of life Lt4 Hypothyroidism Proteomics Reduced ft3 
ProteomicsInvestigating the Cytoprotective Mechanisms of the Tardigrade Damage Suppressor (Dsup) Protein in Human Cells Under Hypoxic Stress
Introduction: Ischemia/reperfusion injury (IRI) is a common damage due to the restoration of blood flow after an ischemic insult. The pathogenesis of IRI is mainly linked to the production of ROS which sustain cell damage and ultimately promote cell death. The tardigrade damage suppressor protein (D...
ORGANISM(S): Homo sapiens (Human) 
2025-11-24 | PXD067125 | Pride
Ischemia Autophagy Reperfusion Dsup Oxidative stress Proteomic 
ProteomicsFIRST ATTEMPT TO COUPLE PROTEOMIC WITH AhR REPORTER GENE BIOASSAY IN SOIL POLLUTION MONITORING AND ASSESSMENT
A topsoil sample obtained from a highly industrialized area was tested on CALUX® cell line and exposed cells processed with proteomic and bioinformatics analyses. GC-MS/MS analysis of topsoil extracts was also performed to confirm PCDD, PCDF and dl-PCBs presence. CALUX® and GC-MS/MS data confirmed ...
ORGANISM(S): Rattus norvegicus (Rat) 
2022-02-17 | PXD027074 | Pride
Dr-calux  proteomics  polychlorinated dibenzo-p-dioxins  polychlorinated dibenzofurans  dioxin-like polychlorinated biphenyls. 
ProteomicsRictor/mTORC2 downregulation in BRAFV600E melanoma cells promotes resistance to BRAF/MEK inhibition
Nearly 50% of cutaneous melanomas carry activating mutations on the BRAF oncogene, and the combination of BRAF- and MEK-inhibitors (BRAF/MEKi) is frequently used for their clinical management. One major drawback of BRAF/MEKi targeted therapy is the rapid development of therapeutic resistance, which ...
ORGANISM(S): Homo sapiens (Human) 
2024-05-23 | PXD045346 | Pride
Brafv600e Mtorc2 Braf Rictor Melanoma 
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