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Proteomicsmyc-SHP2 IP to identify SHP2 interactors through proteomics IP
Missense mutations in PTPN11, which encodes the protein tyrosine phosphatase SHP2, are common in several developmental disorders and cancers. While many mutations disrupt auto-inhibition and hyperactivate SHP2, several do not enhance catalytic activity. Both activating and non-activating mutations c...
ORGANISM(S): Homo sapiens (Human) 
2025-08-31 | PXD067419 | Pride
Shp2 Ptp Ip Interactomics 
ProteomicsSHP2 lysates to identify SHP2 interactors and co-localized protein (total proteome)
Missense mutations in PTPN11, which encodes the protein tyrosine phosphatase SHP2, are common in several developmental disorders and cancers. While many mutations disrupt auto-inhibition and hyperactivate SHP2, several do not enhance catalytic activity. Both activating and non-activating mutations c...
ORGANISM(S): Homo sapiens (Human) 
2025-10-08 | PXD069201 | Pride
Shp2 Hek 293 cells Turboid Phosphatase Total proteome Interactomics Protein-protein interactions 
ProteomicsSHP2 TurboID to identify SHP2 interactors and co-localized protein
Missense mutations in PTPN11, which encodes the protein tyrosine phosphatase SHP2, are common in several developmental disorders and cancers. While many mutations disrupt auto-inhibition and hyperactivate SHP2, several do not enhance catalytic activity. Both activating and non-activating mutations c...
ORGANISM(S): Homo sapiens (Human) 
2025-08-31 | PXD067905 | Pride
Shp2 Hek 293 cells Turboid Interactomics Protein-protein interactions 
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