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ProteomicsSalmonella Typhimurium effector SseI regulates host peroxisomal dynamics to acquire lysosomal cholesterol for better intracellular growth
Intracellular Salmonella resides and multiplies in cholesterol-rich specialized compartment called Salmonella-containing vacuoles (SCVs) and avoids fusion with acidic lysosomes. Given, lysosomes are primary organelle that redistributes LDL derived cholesterol to other organelles; we questioned how l...
ORGANISM(S): Homo sapiens (Human) 
2024-10-28 | PXD055151 | Pride
Salmonella typhimurium Cholesterol Arf1 activation Peroxisome targeting sequence Peroxisomes 
MetabolomicsSerine and 1-carbon metabolism are required for HIF-mediated protection against retinopathy of prematurity
We determined which metabolic pathways are activated by hypoxia-inducible factor 1-mediated (HIF-1-mediated) protection against oxygen-induced retinopathy (OIR) in newborn mice, the experimental correlate to retinopathy of prematurity, a leading cause of infant blindness. HIF-1 coordinates the chang...
2019-07-05 | MTBLS856 | MetaboLights
TranscriptomicsA single functional blast resistance gene Pi54 activates complex defense mechanism in Rice
To investigate the responses of resistance gene Pi54 at transcriptome level in blast resistant transgenic rice line TP-Pi54 during infection by Magnaporthe oryzae, we studied the co-expression analysis using microarray along with susceptible non-transgenic line Taipei 309 (TP). Suitable controls ...
ORGANISM(S): Oryza sativa Japonica Group 
2011-12-08 | E-GEOD-28308 | biostudies-arrayexpress
UnknownAssociation of SUMOylation Pathway Genes With Stroke in a Genome-Wide Association Study in India.
Not available
S-EPMC8362360 | biostudies-literature
TranscriptomicsA Toxoplasma dense granule protein, GRA24, modulates the early immune response to infection by promoting a direct and sustained host p38 MAPK activation
Toxoplasma gondii, the causative agent of toxoplasmosis, is an obligate intracellular protozoan parasite that resides inside a parasitophorous vacuole. During infection, Toxoplasma actively remodels the transcriptome of its hosting cells with profound and coupled impact on the host immune response. ...
ORGANISM(S): Mus musculus 
2013-09-01 | E-GEOD-38782 | biostudies-arrayexpress
ProteomicsRUFY3 links Arl8b and JIP4-Dynein complex to regulate lysosome size and positioning
The whole-cell scale spatial organization of lysosomes is regulated by their bidirectional motility on microtubule tracks. Small GTP-binding (G) protein, Arl8b, stimulates the anterograde transport of lysosomes by recruiting adaptor protein SKIP (also known as PLEKHM2), which in turn couples the mic...
ORGANISM(S): Homo sapiens (Human) 
2022-03-23 | PXD027010 | Pride
Arl8b Lysosome Small gtpase Dynein Microtubule 
GenomicsRole of pgmA in mycobacterial pathogenesis
In this project we present a comprehensive characterization and functional analysis of mycobacterial pgmA focusing on its role in central metabolic flux under different environmental conditions We further analysed its implication in disease biology and pathogenesis We have employed a combination of ...
PRJEB66126 | ENA
UnknownEvaluating prostate biopsy practices across Indian institutions: A multi-center prospective observational study
Not available
S-EPMC12815441 | biostudies-literature
ProteomicsHost cholesterol modulates the generation and enrichment of persister population during Mycobacterium tuberculosis infection.
Post-translational modifications (PTMs) confer diversity to regulatory mechanisms that control various cellular pathways. Two of the most extensively studied PTMs are phosphorylation and acetylation. Together, they are known to regulate the stability and activity of proteins in both eukaryotes and p...
ORGANISM(S): Mycobacterium tuberculosis M24 
2020-10-16 | PXD022028 | Pride
Proteomics Lc-ms/ms 
UnknownqTAG: An adaptable plasmid scaffold for CRISPR-based endogenous tagging
Not available
S-SCDT-10_1038-S44318-024-00337-5 | biostudies-other
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