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ProteomicsIntegrative Network Analysis Reveals USP7 Haploinsufficiency Inhibits E-protein Activity in Pediatric T-lineage Acute Lymphoblastic Leukemia (T-ALL)
USP7, which encodes a deubiquitylating enzyme, is among the most frequently mutated genes in pediatric T-ALL, with somatic heterozygous loss-of-function mutations (haploinsufficiency) predominantly affecting the subgroup that has aberrant TAL1 oncogene activation. Network analysis of >200 T-ALL tran...
ORGANISM(S): Homo sapiens (Human) 
2021-03-16 | PXD023377 | Pride
Tal1 T-all Usp7 
ProteomicsCross talks between mutant Leucine Rich Repeat Kinase 2 in the peripheral immune system and the CNS regulate neurodegeneration after environmental insult - part 1
Missense mutations in the Leucine Rich Repeat Kinase 2 (LRRK2) gene result in late-onset Parkinson’s disease (PD). The incomplete penetrance of LRRK2 mutations in humans and LRRK2 murine models of PD suggests that the disease may result from a complex interplay of genetic predispositions and persist...
ORGANISM(S): Mus musculus (Mouse) 
2018-05-03 | PXD006290 | Pride
Lps Cytokines. Inflammation Lrrk2 Parkinson’s disease Microglia 
MetabolomicsAntiviral metabolite 3'-Deoxy-3',4'-didehydro-cytidine is detectable in serum and identifies acute viral infections including COVID-19

BACKGROUND: There is a critical need for rapid viral infection diagnostics to enable prompt case identification in pandemic settings and support targeted antimicrobial prescribing.

METHODS: Using untargeted high-resolution liquid chromatography coupled with...

2022-02-10 | MTBLS718 | MetaboLights
GenomicsICGC_PACA-AU_20160429 - samples
Additional sequencing data for 173 donors in EGAS00001000154, a study of Pancreatic Ductal Adenocarcinoma. WGS libraries were used for high-cellularity cases, WXS sequencing to high depth on low-cellularity cases. HiSeq 2xxx platform was used in all cases. The analysis files associated with this dat...
EGAD00001002192 | EGA
GenomicsQCMG_20130826 - samples
Analysis .bam files from HiSeq sequencing of Australian ICGC PDAC study samples, submitted 20130826
EGAD00001000660 | EGA
GenomicsQCMG20130201_pancreatic - samples
Sequencing data for Australian Pancreatic Cancer study submitted 20130102
EGAD00001000323 | EGA
GenomicsRNASeq_PACA-AU_Apr_2017 - samples
BAM outputs from RSEM (https://deweylab.github.io/RSEM/) analysis of RNASeq sequencing on HiSeq platform of tumour samples from 95 pancreatic adenocarcinoma cases.
EGAD00001003298 | EGA
GenomicsABO_OICR_DATASET - samples
OICR PANCREATIC CANCER DATASET
EGAD00001000262 | EGA
GenomicsQCMG_PDAC_cell_lines - samples
Sequencing data for PDAC cell lines generated by QCMG
EGAD00001000371 | EGA
GenomicsPancreatic adenocarcinoma QCMG 20120201 - samples
Pancreatic adenocarcinoma QCMG 20120201
EGAD00001000096 | EGA
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