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UnknownLinked PNPLA3 polymorphisms confer susceptibility to nonalcoholic steatohepatitis and decreased viral load in chronic hepatitis B.
Not available
S-EPMC4515841 | biostudies-literature
MetabolomicsClinical efficacy of Yiqi Yangxue formula on knee osteoarthritis and unraveling therapeutic mechanism through plasma metabolites in rats.

OBJECTIVE: To observe the clinical efficacy and safety of Yiqi Yangxue formula (YQYXF) on knee osteoarthritis (KOA), and to explore the underlying therapeutic mechanism of YQYXF through endogenous differential metabolites and their related metabolic pathways.

METHOD...

2024-03-25 | MTBLS5667 | MetaboLights
ProteomicsOncogenic EGFR rewires STING-TBK1 immune machinery by tyrosine phosphorylation to license DNA damage tolerance
EGFR hotspot mutations (mEGFR), including primary drivers such as L858R and exon 19 deletions, and the frequently acquired resistance mutation T790M, are pivotal oncogenic drivers in non-small cell lung cancer (NSCLC). Yet, resistance to third-generation tyrosine kinase inhibitors (TKIs) remains unr...
ORGANISM(S): Homo sapiens (Human) 
2026-07-01 | PXD074679 | Pride
Tyrosine phosphorylation Chemoresistance Cgas-sting Egfr-tkis Egfr Tbk1 
UnknownGut microbiota and common gastrointestinal diseases: a bidirectional two-sample Mendelian randomized study.
Not available
S-EPMC10691374 | biostudies-literature
UnknownEvaluation and Application of Population Pharmacokinetic Models for Identifying Delayed Methotrexate Elimination in Patients With Primary Central Nervous System Lymphoma.
Not available
S-EPMC8959905 | biostudies-literature
UnknownDownregulation of Hypoxia-Inducible Factor-1α by RNA Interference Alleviates the Development of Collagen-Induced Arthritis in Rats.
Not available
S-EPMC7038004 | biostudies-literature
ProteomicsA proteomic landscape of diffuse-type gastric cancer
Here we present a dataset from 84 DGC patients with paired tumor and nearby tissue. Tumors and their nearby tissues were evaluated by pathologists. Nearby tissues were designated as non-cancerous and were greater than 5 cm away from the surgery margin. Hematoxylin and eosin (H&E) stained sections we...
ORGANISM(S): Homo sapiens (Human) 
2018-02-09 | PXD008840 | Pride
Gastric cancer Proteome 
UnknownESTROGEN RECEPTOR EXPRESSION ON BREAST CANCER PATIENTS' SURVIVAL UNDER SHAPE RESTRICTED COX REGRESSION MODEL.
Not available
S-EPMC8570133 | biostudies-literature
MetabolomicsPRODH regultes naive pluripotency by influencing mitochondrial oxidative phosphorylation (Untargeted metabolomics)

Naïve human embryonic stem cells (hESCs) that resemble the pre-implantation epiblasts are fueled by a combination of aerobic glycolysis and oxidative phosphorylation, but their mitochondrial regulators are poorly understood. Here we report that, proline dehydrogenase (PRODH), a mitochondria-local...

2024-02-12 | MTBLS7840 | MetaboLights
UnknownUPLC-Q-TOF/MS-Based Plasma Metabolomics to Evaluate the Effects of Aspirin Eugenol Ester on Blood Stasis in Rats.
Not available
S-EPMC6651160 | biostudies-literature
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