Sort   by:  
 Page size 
TranscriptomicsGenome-wide analysis of the SNAPc complex [Illumina array]
The small nuclear RNA (snRNA)-activating protein complex (SNAPc) is a basal transcription factor that mediates the transcriptional activation of snRNAs. Here, we describe the genome-wide occupancy of the SNAPC1_and SNAPC4 subunits of SNAPc. While the SNAPC4 occupancy was in accord with the role for ...
ORGANISM(S): Homo sapiens 
2012-10-12 | E-GEOD-41528 | biostudies-arrayexpress
ProteomicsINTS6-SOSS1 complex facilitates DNA:RNA hybrid autoregulation at double- strand breaks
This study shows that Integrator complex subunit 6 (INTS6) associates with the trimeric SOSS1 (comprising INTS3, INIP, and hSSB1) to form a tetrameric SOSS1 complex following DNA damage. INTS6 binds to DNA:RNA hybrids and plays a crucial role in Protein Phosphatase 2 (PP2A) recruitment to DNA double...
ORGANISM(S): Homo sapiens (Human) 
2025-05-06 | PXD048694 | Pride
Ints6setx Ints6 Int6 complex 
GenomicsGenome-wide analysis of the SNAPc complex [ChIP-Seq]
The small nuclear RNA (snRNA)-activating protein complex (SNAPc) is a basal transcription factor that mediates the transcriptional activation of snRNAs. Here, we describe the genome-wide occupancy of the SNAPC1 and SNAPC4 subunits of SNAPc. While the SNAPC4 occupancy was in accord with the role for ...
ORGANISM(S): Homo sapiens 
2012-09-28 | E-GEOD-37403 | biostudies-arrayexpress
TranscriptomicsExpression profiles of human primary keratinocytes differentiated with TPA
Human primary keratinocytes were left untreated or treated for 48 hr with 12-O-tetradecanoylphorbol-13-acetate (TPA) and expression profiles were compared to find long ncRNAs expressed and differentially regulated upon differentiation. 4 replicates of minus TPA and 3 of plus TPA with dye-swap. Custo...
ORGANISM(S): Homo sapiens 
2011-04-12 | E-GEOD-28552 | biostudies-arrayexpress
TranscriptomicsGene expression analysis in A549 cells
Snai1 or ncRNA-a7 were knocked down in A549 cells using siRNA and the changes in mRNA levels were determined. Comparative analysis of duplicate microarray experiments compared to control transfected cells.
ORGANISM(S): Homo sapiens 
2011-04-12 | E-GEOD-28558 | biostudies-arrayexpress
ProteomicsNeuronal differentiation requires BRAT1 complex to remove REST from chromatin
Repressor element-1 silencing transcription factor (REST) is required for mature neurons formation. REST dysregulation underlies a key mechanism of neurodegeneration associated with neurological disorders. However, the mechanisms leading to alterations of REST-mediated silencing of key neurogenesis ...
ORGANISM(S): Homo sapiens (Human) 
2025-05-06 | PXD050622 | Pride
Integrator Neuronal differentiation Brat1 
MetabolomicsATAD3A has a scaffolding role regulating mitochondria inner membrane structure and protein assembly

The ATPase Family AAA Domain Containing 3A (ATAD3A), is a mitochondrial inner membrane protein conserved in metazoans. ATAD3A has been associated with several mitochondrial functions, including nucleoid organization, cholesterol metabolism, and mitochondrial translation. To address its primary ro...

2022-01-14 | MTBLS3786 | MetaboLights
TranscriptomicsGenome-wide analysis of the Integrator complex (BeadChip)
We investigated the genomic occupancy of INTS11, in normal condition and after stimulation of EGF. Total RNAPII was profiled in the presence or absence of INTS11, along with the Super Elongation Complex proteins AFF4 and ELL2. Additionally, we extensively examined the transcriptional response to EGF...
ORGANISM(S): Homo sapiens 
2014-09-09 | E-GEOD-58254 | biostudies-arrayexpress
TranscriptomicsGenome-wide analysis of BRCA1 and PALB2 [RA stimulation]
Breast and ovarian cancer susceptibility genes, BRCA1 and PALB2 have enigmatic roles in cellular growth and mammalian development. While these genes are essential for growth during early developmental programs, inactivation later in adulthood leads to increased growth and formation of tumors, leadi...
ORGANISM(S): Homo sapiens 
2013-09-30 | E-GEOD-45714 | biostudies-arrayexpress
GenomicsEnhancer activation during EGF response
We investigated the acetylation of H3K27, in normal condition and after stimulation of EGF and before or after the depletion of INTS11. Additionally, we examined transcription by sequencing the chromatin-bound fraction of RNA and by fractionating total RNA into polyadenylated and non-polyadenylated ...
ORGANISM(S): Homo sapiens 
2015-08-25 | E-GEOD-68401 | biostudies-arrayexpress
Sort   by:  
 Page size