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ProteomicsPhosphoproteomics reveals novel modes of function and inter-relationships among PIKKs in response to genotoxic stress
The DNA damage response (DDR) is a complex signaling network that relies on cascades of protein phosphorylation, which are initiated by three protein kinases of the family of PI3-kinase-related protein kinases (PIKKs): ATM, ATR and DNA-PK. ATM is missing or inactivated in the genome instability syn...
ORGANISM(S): Homo sapiens (Human) 
2020-11-25 | PXD020884 | Pride
Atr Ddr Atm Dna-pk Dna damage 
ProteomicsPhosphoproteomics reveals novel modes of function and inter-relationships among PIKKs in response to genotoxic stress
The DNA damage response (DDR) is a complex signaling network that is robustly mobilized by double-strand breaks (DSBs) in the DNA. This network relies on extensive cascades of protein phosphorylation and dephosphorylation, which are initiated by three apical protein kinases that belong to the family...
ORGANISM(S): Homo sapiens (Human) 
2020-11-25 | PXD015455 | Pride
Human Atr Atm Dna-pk Ddr Lc-ms/ms 
UnknownNuclear poly(A)-binding protein 1 is an ATM target and essential for DNA double-strand break repair.
Not available
S-EPMC5778506 | biostudies-literature
UnknownCondensin I recruitment and uneven chromatin condensation precede mitotic cell death in response to DNA damage.
Not available
S-EPMC2064180 | biostudies-literature
UnknownBroad repression of DNA repair genes in senescent cells identified by integration of transcriptomic data.
Not available
S-EPMC11724277 | biostudies-literature
UnknownFunctional genomic delineation of TLR-induced transcriptional networks.
Not available
S-EPMC2175519 | biostudies-literature
UnknownDAPK2 is a novel regulator of mTORC1 activity and autophagy.
Not available
S-EPMC4326577 | biostudies-literature
TranscriptomicsChronic liver inflammation-induced double strand DNA breaks enhance hepatocarcinogenesis
Surgical resection is the preferred treatment for Hepatocellular carcinoma; however, it induces tumor recurrence. Our objective was to understand the molecular mechanisms linking liver regeneration under chronic-inflammation to tumorigenesis. Mdr2-knockout mice, a model of inflammation-associated ca...
ORGANISM(S): Mus musculus 
2010-01-03 | E-GEOD-14539 | biostudies-arrayexpress
UnknownUBQLN4 promotes STING proteasomal degradation during cisplatin-induced DNA damage in triple-negative breast cancer.
Not available
S-EPMC9286529 | biostudies-literature
UnknownThe COP9 signalosome is vital for timely repair of DNA double-strand breaks.
Not available
S-EPMC4482063 | biostudies-literature
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