Sort   by:  
 Page size 
ProteomicsFollicle-like niches outside the cortex? 3D phase-contrast µCT revealed medullary B cell nodules in mucosa-draining lymph nodes
This study identifies and characterizes previously unrecognized medullary B cell niches within murine mucosa-draining lymph nodes (LNs), challenging the conventional understanding of LN architecture. Utilizing advanced imaging techniques, including synchrotron radiation-based phase-contrast micro-co...
ORGANISM(S): Mus musculus (Mouse) 
2025-11-22 | PXD066656 | Pride
Lymph node niches  mucosal immunity  high endothelial venule (hev)  x-ray microtomography  aging  b cell microenvironment  lymphocyte homing  medulla 
ProteomicsLipid nanotubes unmask neutrophils for complement attack
Neutrophils, critical components of innate immunity, undergo significant morphological changes during phagocytosis. In this study, we demonstrate that neutrophils exposed to shear stress generate lipid nanotubes (NTs) with a unique composition. Compared to the proteome of whole neutrophils, NTs nota...
ORGANISM(S): Homo sapiens (Human) 
2026-09-07 | PXD064111 | Pride
Complement system Shear stress Extracellular vesicles Neutrophils Polytrauma Vasculitis 
ProteomicsExtracellular vesicles released from cortical neurons influence spontaneous activity of recipient neurons.
Extracellular vesicles (EVs) are membranous structures that cells release into the extracellular space. EVs carry various molecules such as proteins, lipids, and nucleic acids, and serve as specialized transporters to influence other cells. In the central nervous system, EVs have been linked to many...
ORGANISM(S): Mus musculus (Mouse) 
2025-09-22 | PXD062783 | Pride
Hippocampus Synaptic activity Nmda receptor Extracellular vesicles Cortex 
ProteomicsInhibition of tumour necrosis factor alpha by Etanercept attenuates Shiga toxin-induced brain pathology
Infection with enterohemorrhagic E. coli (EHEC) causes severe changes in the brain leading to angiopathy, encephalopathy and microglial activation. In this study, we investigated the role of tumour necrosis factor alpha (TNF-α) for microglial activation and brain pathology using a preclinical mouse ...
ORGANISM(S): Mus musculus (Mouse) 
2025-02-18 | PXD052925 | Pride
Microglial activation Brain pathology Tnfα (tumour necrosis factor alpha) Etanercept Ehec (enterohemorrhagic e. coli) 
ProteomicsERG overexpression is a predictive biomarker for PARP-inhibitor-mediated selective radiosensitization in prostate cancer – a proof of concept study
Radiotherapy (RT) is a key treatment for prostate cancer (PCa), relying on the ability to induce DNA damage, particularly double-strand breaks (DSBs). The success of RT depends on tumor radiosensitivity and the ability to repair DSBs, making inhibitors of DSB repair enzymes a potential strategy for ...
ORGANISM(S): Homo sapiens (Human) 
2026-01-08 | PXD060964 | Pride
Prostate cancer Erg overexpression Parp inhibition Dna double-strand break repair Radiotherapy 
ProteomicsCDKL1 risk variants predispose to a connective tissue disorder with thoracic aortic aneurysm and dissection
Genetic factors are fundamental in the etiology of thoracic aortic aneurysm and dissection (TAAD), but the genetic cause is detected in only about 30% of cases. To define unreported TAAD-associated sequence variants, exome and gene panel sequencing was performed in 323 patients. We identified hetero...
ORGANISM(S): Homo sapiens (Human) 
2025-09-09 | PXD048044 | Pride
Cdkl1 Cgmp signaling Thoracic aortic aneurysm and dissection Arterial aneurysm and dissection Hereditary aortopathy Connective tissue disorder 
ProteomicsG-CSF/NAMPT signaling drives neutrophil dysfunction and enhances bacterial infection susceptibility in cancer patients
Despite advancements in cancer therapies, bacterial complications remain a major challenge, delaying treatment and worsening outcomes. While immunosuppressive therapies and prolonged hospitalizations contribute, they do not fully explain the elevated infection risk in cancer patients. Here we show t...
ORGANISM(S): Mus musculus (Mouse) 
2025-11-13 | PXD052631 | Pride
ProteomicsHERC5 alters mitochondrial energy metabolism pathways in NSCLC
In 2020, lung cancer remains the most diagnosed entity among men and third most among women, causing approximately 1.8 million deaths worldwide with an estimated 31.5% of new cases in men and 14.6% in women, respectively (1). Moreover, metastasized non-small cell lung cancer (NSCLC) continues to be ...
ORGANISM(S): Homo sapiens (Human) 
2024-05-24 | PXD045563 | Pride
Nsclc Oxphos Cancer metabolism 
ProteomicsRed blood cell-tumor cell interactions promote tumor cell progression
To be updated. The objective of the project is to compare the proteomic changes happening to the cell line H1975 after being pre-stimulated with red blood cells from different groups of cancer patients.
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD053123 | Pride
Non-small lung cancer 
ProteomicsThe Shewanella oneidensis Fic enzyme SoFic targets theswitch-I region of EF-Tu for AMPylation
Fic enzymes mediate diverse post-translational modifications, including adeno-sine monophosphate (AMP) transfer and removal, referred to as AMPylationand deAMPylation, respectively. We identified the prokaryotic translationelongation factor Tu (EF-Tu) as an AMPylation target of the Fic enzymeSoFic. ...
ORGANISM(S): Escherichia coli 
2026-09-18 | PXD071331 | Pride
Structural regulation Ampylation Ef-tu Fic enzymes Deampylation 
Sort   by:  
 Page size