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The tumor microenvironment determines the clinical response of patients to therapeutic immune checkpoint inhibition (ICI), but a comprehensive understanding of the underlying immune-regulatory proteome is still lacking. To better understand and assess targetable promising biological processes that s...
ORGANISM(S): Homo sapiens (Human) 
2025-03-04 | PXD035502 | Pride
Spectral libraries fulfill multiple functions in biological and analytical applications. For biologists, these libraries provide a valuable resource to verify the presence and abundance of proteins or pathways within a selected cell type thus determine the feasibility of further experiments. Despite...
ORGANISM(S): Mus musculus (Mouse) 
2025-03-06 | PXD059683 | Pride
Infection with enterohemorrhagic E. coli (EHEC) causes severe changes in the brain leading to angiopathy, encephalopathy and microglial activation. In this study, we investigated the role of tumour necrosis factor alpha (TNF-α) for microglial activation and brain pathology using a preclinical mouse ...
ORGANISM(S): Mus musculus (Mouse) 
2025-02-18 | PXD052925 | Pride
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