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UnknownProteome Profile of Myelin in the Zebrafish Brain.
Not available
S-EPMC8060510 | biostudies-literature
ProteomicsProteome profile of myelin in the zebrafish brain
While the myelin proteome is well characterized in mice, much less is known about the protein composition of myelin in non-mammalian species such as zebrafish (Danio rerio), despite its increasing popularity as model organism for myelin biology. Here, we assess the proteome of myelin biochemically p...
ORGANISM(S): Danio rerio (Zebrafish) (Brachydanio rerio) 
2021-03-22 | PXD023037 | Pride
Transcriptome Oligodendrocyte Mbp Label-free proteomics Teleost Cd59 Central nervous system (cns) Mpz Danio rerio Plp Zebrafish Myelin proteome 
UnknownConservation and divergence of myelin proteome and oligodendrocyte transcriptome profiles between humans and mice.
Not available
S-EPMC9094742 | biostudies-literature
UnknownCDC42-Effector Proteins Regulate Higher Order Structure of Septins Required for CNS Myelin Integrity.
Not available
S-EPMC12858042 | biostudies-literature
ProteomicsConservation and divergence of myelin proteome profiles between humans and mice
While myelin is commonly assessed in mice as a model for humans, it remained unclear to which extent their myelin protein composition is similar. We analyzed the proteome of myelin biochemically purified from human white matter by two steps of discontinuous sucrose density gradient centrifugation in...
ORGANISM(S): Homo sapiens (Human) 
2022-05-16 | PXD029727 | Pride
Oligodendrocyte Human post mortem brain tissue Label-free proteomics Mass spectrometry Central nervous system (cns) Autopsy Myelin proteome Translation 
ProteomicsProgressive axonopathy when oligodendrocytes lack the myelin protein CMTM5
Chemokine-like factor-like MARVEL-transmembrane domain containing protein 5 (CMTM5) is a tetraspan-transmembrane protein highly enriched in oligodendrocytes and central nervous system (CNS) myelin. We analyzed the proteome of myelin biochemically purified from mouse brains upon genetic disruption of...
ORGANISM(S): Mus musculus (Mouse) 
2022-04-04 | PXD029443 | Pride
Chemokine-like factor-like marvel-transmembrane domain containing protein (cmtm) family Oligodendrocyte Label-free proteomics Mass spectrometry Central nervous system (cns) Wallerian degeneration Neurodegeneration Myelin proteome 
ProteomicsMyelin proteome alterations upon oligodendroglial deletion of CDC42 and its effector proteins CDC42EP1/CDC42EP2
The regular structure of healthy CNS myelin sheaths requires specialized structural proteins, including septin filaments composed of subunits SEPTIN2, SEPTIN4, SEPTIN7, and SEPTIN8. Their assembly scaffolds the innermost non-compacted myelin layer as a late step of CNS myelin maturation and their di...
ORGANISM(S): Mus musculus (Mouse) 
2025-12-30 | PXD066943 | Pride
Label-free protein quantification White matter Cytoskeleton Oligodendrocyte Septins Mass spectrometry Myelination Myelin pathology Myelin proteome 
UnknownProgressive axonopathy when oligodendrocytes lack the myelin protein CMTM5.
Not available
S-EPMC8916772 | biostudies-literature
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