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ProteomicsComprehensive redox profiling of the thiol proteome of Clostridium difficile
The strictly anaerobic bacterium C. difficile has become one of the most problematic hospital acquired pathogens and a major burden for health care systems. Although antibiotics work effectively in most C. difficile infections (CDIs), their detrimental effect on the intestinal microbiome paves the w...
ORGANISM(S): Peptoclostridium difficile (strain 630) (Clostridium difficile) 
2018-03-05 | PXD007278 | Pride
Thiol redox proteomics Clostridium difficile 
ProteomicsMyxopyronin B inhibits growth of a Fidaxomicin-resistant Clostridioides difficile isolate and interferes with toxin synthesis
Fidaxomicin is considered the current gold standard antibiotic for treating Clostridioides difficile infections and kills bacterial cells by inhibition of the RNA polymerase through binding to its switch region. Although binding sites do not overlap, also Myxopyronin B inhibits the RNA polymerase by...
ORGANISM(S): Peptoclostridium difficile (strain 630) (Clostridium difficile) 
2021-12-21 | PXD027366 | Pride
Clostridioides difficile Rna polymerase inhibitors Fidaxomicin Rifaximin Toxins Antibiotic resistance Antibiotic therapy Myxopyronin b 
ProteomicsFlavodoxin Landscape in Clostridioides difficile
C. difficile infections have become a major challenge in medical facilities today. The bacterium is capable of spore formation, which even allows survival of antibiotic treatment. Therefore, research on the physiology of C. difficile is important for the development of alternative treatment strategi...
ORGANISM(S): Peptoclostridium difficile (strain 630) (Clostridium difficile) 
2024-02-02 | PXD041951 | Pride
Expression profiling Mass spectrometry Parallel reaction monitoring 
ProteomicsThe proteomic response of Clostridioides difficile to the atypical tetracycline amidochelocardin and concomitant dissipation of its proton motive force
Amidochelocardin is an atypical tetracycline which was previously shown to target the bacterial cell membrane although its detailed mode-of-action is still unknown. To gain insight into Clostridioides difficile’s response to membrane targeting antibiotics and to further study the mode-of-action of A...
ORGANISM(S): Peptoclostridium difficile (strain 630) (Clostridium difficile) 
2022-08-04 | PXD029250 | Pride
Clostridioides difficile Amidochelocardin Tetracycline Antibiotic resistance Phenazine biosynthesis Antibiotic therapy Dissipation of the proton motive force 
ProteomicsWithin-host adaptive phenotypic responses of bovine Staphylococcus aureus
The Gram-positive bacterium S. aureus is one of the most common causes of contagious bovine mastitis. A predominant S. aureus clone persists within its host over a long period. In the present study, we compared the surface proteome of two isolates, collected from a naturally infected dairy cow with ...
ORGANISM(S): Staphylococcus aureus 
2021-08-14 | PXD025013 | Pride
Chronic bovine mastitis Surface shaving Biotinylaton Host adaption Staphylococcus aureus Cell surface proteome 
ProteomicsThe proteomic response of Clostridioides difficile to the Chlorotonil A derivative ChtB1-Epo2
The anaerobic, spore-forming pathogen Clostridioides difficile infects the gastrointestinal tract of higher mammals, including humans, and is the major causative agent of antibiotic-associated diarrhea. Moreover, recurrence and re-infection rates after a first successful antibiotic therapy are subst...
ORGANISM(S): Peptoclostridium difficile (strain 630) (Clostridium difficile) 
2023-03-29 | PXD029243 | Pride
Chlorotonil a Clostridioides difficile Antibiotic resistance Antibiotic therapy Colonization resistance Selectivity 
ProteomicsTime-resolved effects of cold atmospheric plasma on E. coli GW-AmxH19 transcriptome and proteome in an emulated wastewater environment
Cold atmospheric plasma has been shown to be effective against a variety of microorganisms. In this study, we used the plasma treatment method wINPlas to unravel effects on an Escherichia coli isolated from hospital wastewater. E. coli GW-AmxH19 incubated in artificial wastewater was treated for 15 ...
ORGANISM(S): Escherichia coli 
2026-09-28 | PXD056785 | Pride
Wastewater Proteomics Antibiotic resistance Cold atmospheric plasma Escherichia coli 
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