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MetabolomicsCell Atlas and Novel Signal Processing Strategy in Primate Insular Cortex

The anterior insular cortex (AIC) is a critical hub integrating exteroceptive and interoceptive information into high-order cognition, yet its neural basis remains incompletely understood. Here, by combining whole-cell-based single-cell transcriptomics with Patch-seq recordings, we resolved and c...

2026-02-28 | MTBLS13927 | MetaboLights
ProteomicsSignal sequence characteristics of periplasm and thylakoid lumen proteins in cyanobacteria revealed using a proximity-based proteomics generated spatial proteome
Cyanobacteria have an inner and outer cell membrane enclosing the periplasm and cell wall and an additional set of membranes called the thylakoid membranes enclosing thylakoid lumen. The periplasm and thylakoid lumen have unique proteomes, but the mechanisms sorting proteins to these locations have ...
ORGANISM(S): Synechococcus sp. PCC 7002 x Microcystis aeruginosa TAIHU98 coculture 
2026-02-09 | PXD058004 | Pride
Signal sequence Cyanobacteria Protein localization Apex2 Proximity-based proteomics 
TranscriptomicsCotranslational signal independent SRP preloading during membrane targeting
Cotranslational targeting into the endoplasmic reticulum (ER) by the Signal Recognition Particle (SRP) is a key event determining polypeptide fate in eukaryotic cells. Here, we globally define the principles and mechanisms of SRP binding and ER targeting in vivo. Cotranslational targeting through SR...
ORGANISM(S): Saccharomyces cerevisiae 
2016-08-03 | E-GEOD-74393 | biostudies-arrayexpress
TranscriptomicsGenome-wide SNP signal intensity scanning to find genes differentiating cows with ovarian pathologies from healthy cows
Ovarian cysts and ovarian hypoplasia are common ovarian pathologies in cattle. The development of these pathologies can be attributed to factors such as uterine infection, stress, milk production, age, reproductive time and inherited genetics. The most common detection procedures are via rectal palp...
ORGANISM(S): Bos taurus 
2017-08-22 | E-MTAB-4874 | biostudies-arrayexpress
Transcriptomicscis sequence effects on gene expression
Sequence and transcriptional variability within and between individuals are typically studied independently. The joint analysis of sequence and gene expression variation provides insight into biological mechanisms that underlie gene regulation and function. We investigated the role of sequence varia...
ORGANISM(S): Homo sapiens 
2008-04-09 | E-GEOD-8394 | biostudies-arrayexpress
TranscriptomicsThe Two-component Signal Transduction System CopRS of Corynebacterium glutamicum is Required for Adaptation to Copper-excess Stress
Copper is an essential cofactor for many enzymes but at high concentrations it is toxic for the cell. Copper ion concentrations ≥50 µM inhibited growth of Corynebacterium glutamicum. The transcriptional response to 20 µM Cu2+ was studied using DNA microarrays and revealed 26 genes that showed a ≥3-f...
ORGANISM(S): Corynebacterium glutamicum ATCC 13032 
2011-09-04 | E-GEOD-27510 | biostudies-arrayexpress
TranscriptomicsNew methods to analyse microarray data that partially lack a reference signal.
ABSTRACT: BACKGROUND: Microarray-based Comparative Genomic Hybridisation (CGH) has been used to assess genetic variability between bacterial strains. Crucial for interpretation of microarray data is the availability of a reference to compare signal intensities to reliably determine presence or diver...
ORGANISM(S): Staphylococcus aureus 
2010-01-20 | E-BUGS-85 | biostudies-arrayexpress
ProteomicsBiogenesis of hepatitis B virus e antigen is driven by translocon-associated protein complex and regulated by conserved cysteine residues within its signal peptide sequence
Hepatitis B virus (HBV) uses e antigen (HBe) which is dispensable for virus infectivity to modulate host immune responses and to achieve viral persistence in human hepatocytes. The HBe precursor (p25) is directed to the endoplasmic reticulum (ER), where cleavage of the signal peptide (sp) gives rise...
ORGANISM(S): Homo sapiens (Human) Hepatitis B virus 
2022-07-01 | PXD025430 | Pride
Hbe Er translocation Hepatitis b virus Hbv precore protein Trap complex Signal peptide Cysteine residues 
TranscriptomicsInterfering with Proximal TLR4 to NF-kappaB Signal Transduction in Human Monocytes
This study investigated the global effect of carbon monoxide (CO) gas (250 ppm) on LPS- induced gene expression in THP-1 cells. CO predominantly suppresses LPS-induced gene response. Of the CO-suppressed genes, 18% were transcription factors and most others were cytokines, chemokines and immune resp...
ORGANISM(S): Homo sapiens 
2010-06-08 | E-GEOD-16193 | biostudies-arrayexpress
TranscriptomicsVariation in homeodomain DNA-binding revealed by high-resolution analysis of sequence preferences
Most homeodomains are unique within a genome, yet many are highly conserved across vast evolutionary distances, implying strong selection on their precise DNA-binding specificities. We determined the binding preferences of the majority (168) of mouse homeodomains to all possible 8-base sequences, re...
ORGANISM(S): Mus musculus 
2010-06-26 | E-GEOD-11239 | biostudies-arrayexpress
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