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ProteomicsComparative Analysis of two Helicobacter pylori Strains using Genomics and Mass Spectrometry-Based Proteomics
Helicobacter pylori, a gastroenteric pathogen believed to have co-evolved with humans for 100.000 years, has a high genetic variability that motivates the study of different H. pylori populations and the diseases caused by them in order to find determinants for disease evolution. In this study we ut...
ORGANISM(S): Helicobacter pylori 
2018-10-26 | PXD005074 | Pride
Protein expression Proteomics Tmt Genomics Maxquant Helicobacter pylori 
ProteomicsTitle- Modulation of implanted aortic scaffold- involvement of ECM and immune proteins
Development of a suitable biological scaffold is an essential pre-requisite for functional development of organ including blood vessel. Biological scaffold prepared by conventional means using physical or chemical agent have been shown to cause damage to the extracellular matrix architecture as well...
ORGANISM(S): Rattus rattus (Black rat) Rattus norvegicus (Rat) 
2026-07-06 | PXD021179 | Pride
Acellular Proteomics Immune Tmt Implant Macrophages Vascular scaffold Syn/allogeneic Extracellular matrix 
ProteomicsGlobal Proteomic Analysis Implicates Hepatic Lipid Droplet-Associated Kinase STK25 in Regulation of Metabolic Stress Response in Steatotic Liver
Non-alcoholic fatty liver disease (NAFLD), defined as fatty infiltration in >5% of hepatocytes (steatosis) in the absence of excessive alcohol consumption, is emerging as a leading cause of liver disease worldwide (1). Subjects with NAFLD have an increased risk of progressing into non-alcoholic stea...
ORGANISM(S): Mus musculus (Mouse) 
2021-09-08 | PXD015311 | Pride
Lipid droplet Stk25 Non-alcoholic fatty liver disease Phosphoproteomics 
ProteomicsMC1R stabilize the actin cytoskeleton
Amplification of the Melanocortin-1 Receptor in Nephrotic Syndrome Renders a Good Target for Podocyte Cytoskeleton Stabilization During the last years, several reports have been presented of beneficial effects of ACTH in patients with nephrotic syndrome. Among the known ACTH receptors, the melanocor...
ORGANISM(S): Mus musculus (Mouse) 
2019-11-12 | PXD009198 | Pride
Mc1r Glomerula Tmt Podocytes Phosphoproteomics Nephrotic syndrome Lc-ms/ms 
ProteomicsMechano-regulated RNA binding protein hnRNPC contributes to RNA homeostasis in heart failure
Cardiac pathologies are characterized by intense remodeling of the extracellular matrix (ECM) that eventually leads to heart failure. Cardiomyocytes respond to the ensuing biomechanical stress by re-expressing fetal contractile proteins via transcriptional and post-transcriptional processes, like al...
ORGANISM(S): Homo sapiens (Human) 
2026-07-06 | PXD020663 | Pride
Proteomics Tmt Ip Hnrnpc Heart failure Rna homeostasis 
ProteomicsCharacterisation of a cell-free myxoid liposarcoma patient-derived xenograft scaffold model
Myxoid liposarcoma (MLS) is the second most common type of liposarcoma, and today few model systems to study the disease exists. To be able to model the disease in vitro, cell-free scaffolds from MLS patient-derived xenograft (PDX) models were generated. The MLS scaffolds were then used as a 3D grow...
ORGANISM(S): Homo sapiens (Human) 
2024-05-08 | PXD023792 | Pride
Cancer Human Fus-ddit3 expression and tumor microenvironment 
ProteomicsATR inhibition enables complete tumour regression in ALK-driven NB mouse models
High-risk neuroblastoma (NB) often involves amplification of the neural MYC (MYCN) oncogene as well as mutations in ALK. Currently, high-risk NB presents significant clinical challenges, and additional therapeutic options are needed. Oncogenes such as MYCN and ALK result in increased replication str...
ORGANISM(S): Homo sapiens (Human) 
2021-11-02 | PXD027187 | Pride
Neuroblastoma Atr inhibitor Phosphorylation Alk 
ProteomicsA Macrophage-Collagen Fragment Axis Mediates Subcutaneous Adipose Tissue Remodeling
Efficient collagen degradation is essential for adaptive subcutaneous adipose tissue (SAT) expansion that protects against ectopic lipid deposition during weight gain. Here, we aimed to further define the mechanism for this collagenolytic process. We show that loss of collagen type-1 (CT1) and incre...
ORGANISM(S): Mus musculus (Mouse) 
2024-06-16 | PXD043721 | Pride
Collagen fragments Macrophages Fibrosis Ecm-remodeling Collagen endocytosis Subcutaneous adipose tissue Cd206 
ProteomicsSubtyping of cardiac amyloidosis by mass spectrometry-based proteomics of endomyocardial biopsies
Cardiac amyloidosis is a severe clinical condition leading to restrictive cardiomyopathy and heart failure. With increasing options for specific treatment of different cardiac amyloid diseases, correct amyloid subtyping is essential for clinical outcome. Mass spectrometry-based methods for cardiac a...
ORGANISM(S): Homo sapiens (Human) 
2022-10-27 | PXD033168 | Pride
Subtyping Proteomics Endomyocardial biopsies Mass spectrometry Cardiac amyloidosis 
ProteomicsSubtyping of cardiac amyloidosis by mass spectrometry-based proteomics of endomyocardial biopsies
Additional data to PXD033168 Cardiac amyloidosis is a severe clinical condition leading to restrictive cardiomyopathy and heart failure. With increasing options for specific treatment of different cardiac amyloid diseases, correct amyloid subtyping is essential for clinical outcome.
ORGANISM(S): Homo sapiens (Human) 
2026-09-21 | PXD047125 | Pride
Proteomics Endomyocardial biopsies Mass spectrometry Cardiac amyloidosis Subtyping 
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