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ProteomicsMaximally-multiplexed proteome quantification platform for isotopic metabolic and chemical labeling
Quantitative proteomic platforms based on precursor intensity in mass spectrometry (MS1-level) uniquely support in vivo metabolic labeling with superior quantification accuracy but suffers from limited multiplexity (≤3-plex) and frequent missing quantities. Herein, we present a maximally-multiplexed...
ORGANISM(S): Homo sapiens (Human) 
2020-03-19 | PXD009952 | Pride
Diethylation Heat shock Silac-6plex Protein quantification Hela cell Quantification Silac De-6plex Heat shock response 
ProteomicsHIGD2A is required for assembly of the COX3 module of human mitochondrial complex IV
Assembly factors play a critical role in the biogenesis of mitochondrial respiratory chain complexes I-IV where they assist in the membrane insertion of subunits, attachment of co-factors, and stabilization of assembly intermediates. The major fraction of complexes I, III and IV are present together...
ORGANISM(S): Homo sapiens (Human) 
2020-04-22 | PXD016864 | Pride
Assembly factor Cytochrome c oxidase Hypoxia Respirasome Oxphos 
ProteomicsProteomic Analysis of Neural Stem Cell to Oligodendrocyte Precursor Cell Differentiation Reveals Phosphorylation-Dependent Dclk1 Processing
The differentiation from neural stem cells (NSCs) to oligodendrocyte precursor cells (OPCs) is only incompletely understood. In the current study, we used the so-called neurosphere assay to study this process. We performed in vitro differentiation from neurospheres (which predominantly consist of NS...
ORGANISM(S): Mus musculus (Mouse) 
2023-08-18 | PXD040652 | Pride
Phosphoproteomics Neural stem cells Dimethyl Tmt Dclk1 Neural development Proximity biotinylation Oligodendrocyte precursor cells Silac Differentiation Isobaric labeling Pura 
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