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TranscriptomicsSIN3A-regulated LIF-responsive genes in MCF7 cells
Tyrosine phosphorylation is a hallmark for activation of Signal Transducer and Activator of Transcription (STAT) proteins, but their transcriptional activity also depends on other secondary modifications. Type I interferons (IFNs) can activate both the ISGF3 (STAT1:STAT2:IRF9) complex and STAT3, but...
ORGANISM(S): Homo sapiens 
2012-08-01 | E-GEOD-35696 | biostudies-arrayexpress
GenomicsGenome-wide maps of Sin3A and Sin3B binding in C2C12 myoblasts and differentiated myotubes
Sin3A and Sin3B bind to distinct and overlapping target sites. Sin3 proteins bind to distinct sites in cycling myoblasts whereas there is a converge of Sin3A and Sin3B proteins to sites in differentiated myotubes. We identified a subset of Sin3 target genes involved in muscle differentiation and phy...
ORGANISM(S): Mus musculus 
2011-01-01 | E-GEOD-22554 | biostudies-arrayexpress
ProteomicsSIN3A Acetylation Complex - Fam60a defines a variant Sin3a-Hdac complex in embryonic stem cells required for self-renewal
Sin3a is the central scaffold protein of the prototypical Hdac1/2 chromatin repressor complex, crucially required during early embryonic development for the growth of pluripotent cells of the inner cell mass. Here, we explore the endogenous composition of the Sin3a-Hdac complex in pluripotent embryo...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2017-05-19 | PXD005464 | Pride
Self-renewal Sin3a complex Embryonic stem cell Fam60a 
TranscriptomicsTet1 and hydroxymethylcytosine in transcription and DNA methylation fidelity (Affymetrix gene expression data)
Enzymes catalyzing the methylation of the 5-position of cytosine (mC) have essential roles in regulating gene expression, genome stability, and maintaining cellular identity. Recently Tet1, which is highly expressed in embryonic stem (ES) cells, was found to oxidize the methyl group of mC converting...
ORGANISM(S): Mus musculus 
2011-04-13 | E-GEOD-24842 | biostudies-arrayexpress
ProteomicsBAHCC1 promotes gene expression in neuronal cells by antagonizing SIN3A-HDAC1
Chromatin modifications play a key role in regulating gene expression during development and adult physiology. Histone acetylation, particularly H3K27ac, is associated with increased activity of gene regulatory elements such as enhancers and promoters. However, the regulation of the machinery that w...
ORGANISM(S): Homo sapiens (Human) 
2025-06-12 | PXD058811 | Pride
Neurons Acetylation Sin3a Hdac Bahcc1 
TranscriptomicsCharacterization of t(15;21) translocations in myeloid disorders
We report on two novel t(15;21) alterations [t(15;21)(q24;q22) and t(15;21)(q21;q22)], which led to concurrent disruption of RUNX1 and two translocation partner genes encoding for transcription factors (SIN3A, TCF12) Examination of four different patients with myeloid disorders. 2 out of 4 have been...
ORGANISM(S): Homo sapiens 
2016-07-29 | E-GEOD-71551 | biostudies-arrayexpress
GenomicsTet1 and hydroxymethylcytosine in transcription and DNA methylation fidelity (ChIP/DIP-Seq data)
We analyzed the genome-wide binding of Tet1 in control (shScr) and Tet1 knockdown (shTet1) mouse ES cells using two different Tet1 antibodies (Tet1-C and Tet1-N). Furthermore, we generated genome-wide mapping of hydroxymethyl cytosine (hmC) and methyl cytosine (mC). We find that hmC, in contrast to ...
ORGANISM(S): Mus musculus 
2011-04-13 | E-GEOD-24841 | biostudies-arrayexpress
TranscriptomicsTranscriptome analysis upon SIN3 or dKDM5/LID knockdown or both under normal and paraquat induced stress conditions in Drosophila S2 cultured cells
SIN3 the scaffold protein of a histone deacetylase complex interacts with a histone demethylase KDM5 (little imaginal discs - LID) in Drosophila. Reduction of SIN3 or dKDM5/LID both result in similar phenotypes during cell proliferation and wing development. To identify underlying transcriptional ch...
ORGANISM(S): Drosophila melanogaster 
2016-01-09 | E-GEOD-68775 | biostudies-arrayexpress
GenomicsFam60a defines a embryonic stem cell specific Sin3a/Hdac complex.
ChIP coupled with NGS identifies genome-wide binding sites of a ES cells specific Sin3a/Hdac complex. The aim of these experiments is to study the role of Fam60a in the Sin3a/Hdac complex. ChIP-Seq experiments reveal that Fam60a is required to maintain high levels of Sin3a binding on target genes in...
ORGANISM(S): Mus musculus 
2017-04-24 | GSE81081 | GEO
UnknownThe SIN3A/HDAC Corepressor Complex Functionally Cooperates with NANOG to Promote Pluripotency.
Not available
S-EPMC5328122 | biostudies-literature
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