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GenomicsGenome-wide maps of Sin3A and Sin3B binding in C2C12 myoblasts and differentiated myotubes
Sin3A and Sin3B bind to distinct and overlapping target sites. Sin3 proteins bind to distinct sites in cycling myoblasts whereas there is a converge of Sin3A and Sin3B proteins to sites in differentiated myotubes. We identified a subset of Sin3 target genes involved in muscle differentiation and phy...
ORGANISM(S): Mus musculus 
2011-01-01 | E-GEOD-22554 | biostudies-arrayexpress
TranscriptomicsSIN3A-regulated LIF-responsive genes in MCF7 cells
Tyrosine phosphorylation is a hallmark for activation of Signal Transducer and Activator of Transcription (STAT) proteins, but their transcriptional activity also depends on other secondary modifications. Type I interferons (IFNs) can activate both the ISGF3 (STAT1:STAT2:IRF9) complex and STAT3, but...
ORGANISM(S): Homo sapiens 
2012-08-01 | E-GEOD-35696 | biostudies-arrayexpress
ProteomicsSIN3A Acetylation Complex - Fam60a defines a variant Sin3a-Hdac complex in embryonic stem cells required for self-renewal
Sin3a is the central scaffold protein of the prototypical Hdac1/2 chromatin repressor complex, crucially required during early embryonic development for the growth of pluripotent cells of the inner cell mass. Here, we explore the endogenous composition of the Sin3a-Hdac complex in pluripotent embryo...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2017-05-19 | PXD005464 | Pride
Self-renewal Sin3a complex Embryonic stem cell Fam60a 
TranscriptomicsCharacterization of t(15;21) translocations in myeloid disorders
We report on two novel t(15;21) alterations [t(15;21)(q24;q22) and t(15;21)(q21;q22)], which led to concurrent disruption of RUNX1 and two translocation partner genes encoding for transcription factors (SIN3A, TCF12) Examination of four different patients with myeloid disorders. 2 out of 4 have been...
ORGANISM(S): Homo sapiens 
2016-07-29 | E-GEOD-71551 | biostudies-arrayexpress
TranscriptomicsTet1 and hydroxymethylcytosine in transcription and DNA methylation fidelity (Affymetrix gene expression data)
Enzymes catalyzing the methylation of the 5-position of cytosine (mC) have essential roles in regulating gene expression, genome stability, and maintaining cellular identity. Recently Tet1, which is highly expressed in embryonic stem (ES) cells, was found to oxidize the methyl group of mC converting...
ORGANISM(S): Mus musculus 
2011-04-13 | E-GEOD-24842 | biostudies-arrayexpress
GenomicsSin3A mutant pancreatic islets
Sin3A mutant pancreatic islets
PRJNA610630 | ENA
TranscriptomicsTranscriptome analysis upon SIN3 or dKDM5/LID knockdown or both under normal and paraquat induced stress conditions in Drosophila S2 cultured cells
SIN3 the scaffold protein of a histone deacetylase complex interacts with a histone demethylase KDM5 (little imaginal discs - LID) in Drosophila. Reduction of SIN3 or dKDM5/LID both result in similar phenotypes during cell proliferation and wing development. To identify underlying transcriptional ch...
ORGANISM(S): Drosophila melanogaster 
2016-01-09 | E-GEOD-68775 | biostudies-arrayexpress
ProteomicsBAHCC1 promotes gene expression in neuronal cells by antagonizing SIN3A-HDAC1
Chromatin modifications play a key role in regulating gene expression during development and adult physiology. Histone acetylation, particularly H3K27ac, is associated with increased activity of gene regulatory elements such as enhancers and promoters. However, the regulation of the machinery that w...
ORGANISM(S): Homo sapiens (Human) 
2025-06-12 | PXD058811 | Pride
Neurons Acetylation Sin3a Hdac Bahcc1 
GenomicsEpstein Barr Virus Nuclear Antigen 3C binds to BATF/IRF4/SPI1 sites and represses CDKN2A by recruiting Sin3A
We report the application of ChIP Seq to study the Epstein Barr Virus Nuclear Antigen 3C, an essential transcriptional regulator involved in the transformation of Resting B Lymphocytes to the immortalized Lymphoblast Cell Lines Examination of viral and cellular transcription factors in 1 type of cel...
ORGANISM(S): Homo sapiens 
2013-12-22 | E-GEOD-52632 | biostudies-arrayexpress
GenomicsAnalysis of SIN3A/B functions within HEK293T cells.
Analysis of SIN3A/B functions within HEK293T cells.
PRJNA510079 | ENA
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