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ProteomicsA cis-regulatory element controls HDAC9 expression to fine-tune inflammasome-dependent chronic inflammation
To understand the underlying molecular mechanism of Hdac9-mediated inflammasome activation and motivated by the molecular scaffolding function of HDAC9, we pursued the hypothesis that HDAC9 may serve as a docking site for cytosolic inflammasome components thereby facilitating its rapid formation upo...
ORGANISM(S): Homo sapiens (Human) 
2025-07-10 | PXD042078 | Pride
Inflammation Inflammasome Atherosclerosis Hdac9 Nlrp3 
GenomicsPhyloepigenetic comparison of apes
We have determined methylation state differences in the epigenomes of neutrophils purified from human and chimpanzee. We used deep sequencing of ends generated by digestion with a methylation-sensitive restriction enzyme, followed by analysis with the MetMap computational pipeline to infer methylati...
ORGANISM(S): Pongo pygmaeus 
2011-09-09 | E-GEOD-22376 | biostudies-arrayexpress
UnknownZBP1 regulates mRNA stability during cellular stress.
Not available
S-EPMC2064588 | biostudies-literature
ProteomicsHistone deacetylase inhibitors cause the selective depletion of bromodomain containing proteins
Histone deacetylases (HDACs) and acetyltransferases control the epigenetic regulation of gene expression through modification of histone marks. Histone deacetylase inhibitors (HDACi) are small molecules that interfere with histone tail modification thus altering chromatin structure and epigeneticall...
ORGANISM(S): Homo sapiens (Human) 
2015-03-18 | PXD001660 | Pride
Gene expression Bromodomain Nucleus Hdaci Lc-ms/ms 
UnknownPriority setting for new technologies in medicine: qualitative case study.
Not available
S-EPMC27534 | biostudies-literature
ProteomicsSpatial tissue proteomics quantifies inter- and intra-tumor heterogeneity in hepatocellular carcinoma
The inter-patient variability of tumor proteomes has been investigated on a large scale but many tumors display also intra-tumoral heterogeneity (ITH) regarding morphological and genetic features. To what extent the local proteome of tumors intrinsically differs remains largely unknown. Here, we use...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2018-01-24 | PXD007052 | Pride
Intra-tumoral heterogeneity Liver Hepatocellular carcinoma 
UnknownDays Spent at Home and Mortality After Critical Illness: A Cluster Analysis Using Nationwide Data.
Not available
S-EPMC10107061 | biostudies-literature
TranscriptomicsBCL6 ChIP on chip using a Nimblegen custom tiling array
To determine whether BCL6 binds to the certain locus we performed genomic localization studies by chromatin immunoprecipitations (ChIP) using a densely tiled custom oligonucleotide microarray covering the genomic loci of different genes. Keywords: ChIP-chip, Transcription Factor localization The ex...
ORGANISM(S): Homo sapiens 
2010-06-10 | E-GEOD-7673 | biostudies-arrayexpress
UnknownPhyloepigenomic comparison of great apes reveals a correlation between somatic and germline methylation states.
Not available
S-EPMC3227095 | biostudies-literature
MetabolomicsUPLC-Q-TOF/MS-Based Plasma and Urine Metabolomics Contribute to the Diagnosis of Sepsis
In this study, we aimed to identify potential metabolic biomarkers that can improve the diagnostic accuracy of sepsis. Sixty-six patients including 30 septic and 36 nonsepsis patients from an intensive care unit were recruited. The global plasma and urine metabolomic profiles were determined by ultr...
2023-04-18 | MTBLS3505 | MetaboLights
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