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ProteomicsIntegrated Fibre-Specific Methylome and Proteome Profiling of Human Skeletal Muscle Across Males and Females with Fibre-Type Deconvolution.
We simultaneously extracted DNA and protein from >200 single fibres per participant (7 males, 5 females) to directly compare methylome and proteome profiles of Type I and Type II human skeletal muscle fibres. Using the EPICv2 array and LC-MS/MS, we identified 5,689 robust DMRs (FDR <0.001) and 338 D...
ORGANISM(S): Homo sapiens (Human) 
2025-10-13 | PXD066393 | Pride
Human skeletal muscle  muscle fibres  type i (slow-twitch)  type ii (fast-twitch)  dna methylation  proteome  lc-ms/ms  epicv2 infinium array  deconvolution  myometh  myotype. 
ProteomicsProteomics reveals a fibre-type specific mitochondrial remodelling with moderate- but not very high-intensity training
Methods for studying mitochondrial adaptations in skeletal muscle have mostly used whole-muscle samples, where results may be confounded by the presence of a mixture of type I and II skeletal muscle fibres. In this project, we utilised the latest Mass spectrometry (MS) techniques to provide new insi...
ORGANISM(S): Homo sapiens (Human) 
2024-10-17 | PXD036010 | Pride
Exercise Proteomics Training Single fibre Fibre type 
ProteomicsProteomic analysis of single muscle fibres from WT and C18ORF25 KO mice
C18ORF25 is a homolog of Arkadia (RNF111), an E3 ubiquitin ligase with SUMO-interaction motifs (SIMs) (PMID: 31417085). However, C18ORF25 lacks the entire C-terminal RING domain of RNF111 which is required for ubiquitin binding suggesting it lacks ubiquitination activity and may therefore act as an ...
ORGANISM(S): Mus musculus (Mouse) 
2024-01-03 | PXD045631 | Pride
Single muscle fibre proteomics C18orf25 
ProteomicsSkeletal Muscle Metabolism of the Astyanax mexicanus
The muscle composition of cave dwelling and surface fish was analyzed by proteomics. Specifically, the composition of the myosin heavy chain was determined by in-gel digestion followed by reversed phase LC-MS/MS. The proteome of the different muscle types was analyzed by tandem mass tags and phosph...
ORGANISM(S): Astyanax Mexicanus (ncbitaxon:7994) 
2021-02-12 | MSV000086857 | MassIVE
ProteomicsFibre Type–Specific Proteomics Reveals Shared and Distinct Skeletal Muscle Adaptations to Resistance Training and Beta2‐Adrenergic Agonist
BackgroundSkeletal muscle is essential for metabolic health and physical function. While resistance training promotes muscle hypertrophy, alternative therapeutic strategies are needed for individuals unable to engage in physical activity. Because beta2-adrenergic stimulation induces muscle growth wi...
ORGANISM(S): Homo sapiens (Human) 
2026-01-26 | PXD064789 | Pride
ProteomicsResting skeletal muscle reduces ATP turnover during hibernation
In mammals, loss of food intake and reduced mechanical loading/activity of skeletal muscles leads to a very rapid loss in mass and function. However, during hibernation in bears, despite spending months without feeding and with very modest muscle activity, only moderate muscle wasting is observed. P...
ORGANISM(S): Ursus arctos (Brown bear) (Grizzly bear) 
2024-12-06 | PXD050980 | Pride
Bear Hibernation Skinned muscle fibers Single muscle fiber 
ProteomicsSarcoglycan interactions in murine muscle membranes
The sarcoglycan complex (SC) is part of a network that links the striated muscle cytoskeleton to the basal lamina across the sarcolemma. The SC coordinates changes in phosphorylation and Ca++-flux during mechanical deformation, and these processes are disrupted with loss-of-function mutations in gam...
ORGANISM(S): Mus musculus (Mouse) 
2022-02-16 | PXD028584 | Pride
Muscle proteomics Immunoaffinity purification Sarcoglycan complex Shotgun proteomics Sarcolemma Limb girdle muscular dystrophy Skeletal muscle Archvillin Membrane biochemistry Protein-protein interactions 
ProteomicsM.musculus - Muscle, SC (Murgiaetal.,emborep2015)
abundance based on Spectral counting, Interaction consistency score: 10.1, Coverage: 7
ORGANISM(S): 10090 
2015-00-00 | 3776918402 | PAXDB
ProteomicsEnlightening the decay: a combined experimental and computational analysis of mantATP turnover in skinned muscle fibers
Myosin is the primary motor protein in skeletal muscle, responsible for ATP hydrolysis that drives muscle contraction. In addition to force production, myosin consumes ATP during rest in futile cycles, a phenomenon associated with the Super Relaxed State (SRX), distinct from the disordered Relaxed S...
ORGANISM(S): Oryctolagus cuniculus (Rabbit) 
2025-04-30 | PXD060451 | Pride
Myh extraction Ghost fiber Single cell Muscle 
ProteomicsM.musculus - Muscle, SC (Murgiaetal.,emborep2015)
abundance based on Spectral counting, Interaction consistency score: 9.7, Coverage: 7
ORGANISM(S): 10090 
2015-00-00 | 2900286163 | PAXDB
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