Sort   by:  
 Page size 
TranscriptomicsMouse sinoatrial node transcriptome
RNA Sequencing of Mouse Sinoatrial Node Reveals an Upstream Regulatory Role for Islet-1 in Cardiac Pacemaker Cells Rationale: Treatment of sinus node disease with regenerative or cell-based therapies will require a detailed understanding of gene regulatory networks in cardiac pacemaker cells (PCs)....
ORGANISM(S): Mus musculus 
2015-02-06 | E-GEOD-65658 | biostudies-arrayexpress
ProteomicsQuantitative proteomics profiling determines the uniqueness of the sinus node
The sinus node is a collection of highly specialized cells that constitute the natural pacemaker activity of our heart. The protein expression landscape of the sinus node differs from the surrounding cardiac tissue, although it is primarily comprised of myocytes and fibroblasts like the rest of the ...
ORGANISM(S): Mus musculus (Mouse) 
2019-07-08 | PXD008736 | Pride
Pacemaker Heart Tissue Sinus node Mouse Conduction Lc-ms/ms 
ProteomicsProteomics Couples Electrical Remodeling to Inflammation in a Murine Model of Heart Failure with Sinus Node Dysfunction
In patients with heart failure, concomitant sinus node dysfunction (SND) is an important predictor of mortality, yet its molecular underpinnings are poorly understood. Here, we acquired deep sinus node proteomes and phosphoproteomes in mice with heart failure and SND and report extensive remodelling...
ORGANISM(S): Mus musculus (Mouse) 
2024-04-25 | PXD031084 | Pride
Lc-msms Phosphoproteomics Phosphopeptide enrichment Q-exactive hf-x Heart Mouse Tmt labeling Fractionation Sinus node Proteomics Orbitrap Sinoatrial node 
GenomicsAlectinib Induces Sinus Bradycardia through Inhibiting Cacna1d Expression, Mediating Electro-Dysfunction in Sinus Node
Alectinib Induces Sinus Bradycardia through Inhibiting Cacna1d Expression, Mediating Electro-Dysfunction in Sinus Node
PRJNA1142437 | ENA
TranscriptomicsExpression profiling of the forming atrioventricular node using a novel Tbx3-based node-specific transgenic reporter
The atrioventricular (AV) node is a recurrent source of potentially life-threatening arrhythmias. Nevertheless, limited data are available on its developmental control or molecular phenotype. We used a novel AV node-specific reporter mouse to gain insight into the gene programs determining the forma...
ORGANISM(S): Mus musculus 
2009-06-02 | E-GEOD-13614 | biostudies-arrayexpress
ProteomicsPhosphoproteomics evaluation of the effect of GLP-1 on the porcine pacemaker
GLP-1 induces an increase in heart rate, but its mechanism remains elusive. We used a phosphoproteomic approach to evaluate the effect of GLP-1 on the porcine sinus node. Tissue samples from the sinus node region and left ventricle were collected from eight animals following a 60-minute infusion wit...
ORGANISM(S): Sus scrofa domesticus (domestic pig) 
2024-06-10 | PXD042583 | Pride
Heart Phosphoproteomics Pig Pacemaker Glucagon-like peptide 1 Porcine Glp-1 Sinus node 
TranscriptomicsMelanoma-derived extracellular vesicles mediate lymphatic remodeling and impair tumor immunity in draining lymph nodes
We investigated transcriptional changes in lymph node resident lymphatic endothelial cells and medullary sinus macrophages upon interactions with melanoma cell-derived extracellular vesicles using single-cell RNA sequencing.
ORGANISM(S): Mus musculus 
2022-03-10 | E-MTAB-10434 | biostudies-arrayexpress
GenomicsQuantitative proteomic and single-nucleus transcriptomics map of the sinus node elucidates the foundation of cardiac pacemaking
Quantitative proteomic and single-nucleus transcriptomics map of the sinus node elucidates the foundation of cardiac pacemaking
PRJNA541019 | ENA
GenomicsPITX2 dosage-dependent pacemaker cell state changes underlie sinus node dysfunction and atrial arrhythmia-susceptibility III
PITX2 dosage-dependent pacemaker cell state changes underlie sinus node dysfunction and atrial arrhythmia-susceptibility III
PRJNA1235194 | ENA
GenomicsPITX2 dosage-dependent pacemaker cell state changes underlie sinus node dysfunction and atrial arrhythmia-susceptibility I
PITX2 dosage-dependent pacemaker cell state changes underlie sinus node dysfunction and atrial arrhythmia-susceptibility I
PRJNA1235178 | ENA
Sort   by:  
 Page size