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TranscriptomicsA role for SIR-2.1 regulation of ER stress response genes in determining C. elegans life span
This SuperSeries is composed of the following subset Series: GSE4093: Resveratrol treatment of daf-16 mutant C. elegans GSE4094: N2 worms treated with Resveratrol GSE4095: Sir-2.1 low copy transgenic Abstract: C. elegans SIR-2.1, a member of the Sir-2 family of NAD(+)-dependent protein deacetylases...
ORGANISM(S): Caenorhabditis elegans 
2006-03-07 | E-GEOD-4402 | biostudies-arrayexpress
TranscriptomicsSir-2.1 low copy transgenic
An all pairs experiment design type is where all labeled extracts are compared to every other labeled extract. Genotype: unc-119+ transgenic worm Computed
ORGANISM(S): Caenorhabditis elegans 
2006-01-24 | E-GEOD-4095 | biostudies-arrayexpress
UnknownA nonhistone protein-protein interaction required for assembly of the SIR complex and silent chromatin.
Not available
S-EPMC1140625 | biostudies-literature
UnknownStability Analysis of SIR Model with Distributed Delay on Complex Networks.
Not available
S-EPMC4973911 | biostudies-literature
TranscriptomicsChromatin immunoprecipitation of Sir-2.1 low copy transgenic C.elegans
Not available
ORGANISM(S): Caenorhabditis elegans 
2005-11-07 | E-SMDB-3540 | biostudies-arrayexpress
GenomicsRNA Immunoprecipitation and Sequencing of Isolated RNAs (RIP-SIR) Identifies Endogenous miRNA-Target Interactions
RNA Immunoprecipitation and Sequencing of Isolated RNAs (RIP-SIR) Identifies Endogenous miRNA-Target Interactions
PRJNA986494 | ENA
UnknownSIR proteins create compact heterochromatin fibers.
Not available
S-EPMC6298083 | biostudies-literature
ProteomicsSir4 H-BRCT domain interacts with multiple phospho-proteins to regulate heterochromatic repression
In Saccharomyces cerevisiae, the Silent Information Regulator (SIR) proteins Sir2/3/4 form a complex suppressing transcription of genes at subtelomeric regions and the homothallic mating type (HM) loci. Here we identify a non-canonical BRCA1 C-terminal domain (H-BRCT) in Sir4 which is responsible fo...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2019-09-13 | PXD014119 | Pride
Tom1 Sir complex Heterochromatin Brct Dbf4 
TranscriptomicsRNA Immunoprecipitation and Sequencing of Isolated RNAs (RIP-SIR) Identifies Endogenous miRNA-Target Interactions
MicroRNAs (miRNAs) are crucial post-transcriptional regulators of gene expression in species ranging from plants to mammals. Unraveling the complex networks of miRNA-mediated regulation of gene expression requires the ability to identify the mRNA targets of individual miRNAs in native cellular conte...
ORGANISM(S): Mus musculus 
2024-12-31 | GSE235579 | GEO
ModelsRoda2020 - SIR model of COVID-19 spread in Wuhan
=Since the COVID-19 outbreak in Wuhan City in December of 2019, numerous model predictions on the COVID-19 epidemics in Wuhan and other parts of China have been reported. These model predictions have shown a wide range of variations. In our study, we demonstrate that nonidentifiability in model cali...
2024-09-02 | BIOMD0000000957 | BioModels
COVID-19 
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