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TranscriptomicsTranscription profiling of human skin biopsies in cutaneous T-cell lymphoma
Cutaneous T cell lymphoma (CTCL) is defined by infiltration of activated and malignant T cells in skin. The clinical manifestations and prognosis in CTCL are highly variable. In this study, we hypothesized that gene expression analysis in lesional skin biopsies can improve understanding of the disea...
ORGANISM(S): Homo sapiens 
2008-06-16 | E-GEOD-9479 | biostudies-arrayexpress
TranscriptomicsA single intradermal injection of IFN-gamma induces a psoriasis-like state in both non-lesional psoriatic and healthy skin
Psoriasis is a chronic, debilitating, immune-mediated inflammatory skin disease. As IFN-gamma is involved in many cellular processes, including activation of T cells and dendritic cells (DCs), antigen processing and presentation, cell adhesion and trafficking, and cytokine and chemokine production, ...
ORGANISM(S): Homo sapiens 
2011-11-30 | E-GEOD-32407 | biostudies-arrayexpress
ProteomicsSkin cancer-associated S. aureus downregulates DNA repair mechanisms, and promotes oxidative stress and DNA damage in human keratinocytes
Actinic keratoses (AK) are premalignant lesions common on photo-damaged skin that, over time, can progress to squamous cell carcinoma (SCC). A high bacterial load of Staphylococcus aureus is associated with AK and SCC but it is unknown whether this has a direct impact on skin cancer development. To ...
ORGANISM(S): Staphylococcus Capitis Staphylococcus Aureus Staphylococcus Epidermidis Staphylococcus 
2022-05-17 | PXD031676 | panorama
TranscriptomicsGene expression in psoriasis lesions and uninvolved skin
Psoriasis is a chronic inflammatory skin disease characterized by marked proliferation of keratinocytes leading to pronounced epidermal hyperplasia, elongation of rete ridges and hyperkeratosis. The most common form of psoriasis, chronic plaque psoriasis (Psoriasis vulgaris), involves relatively sta...
ORGANISM(S): Homo sapiens 
2013-12-10 | E-GEOD-50790 | biostudies-arrayexpress
TranscriptomicsGenome-wide expression profiling of leprosy and granuloma annulare skin lesions
Here we report the data generated by short-read sequencing of mRNA (polyA) isolated from granuloma annulare and leprosy skin lesions. Our main aim was to identify putative mRNA biomarkers for distinguishing leprosy from other differential diagnoses. Additionally, we also explored the distinction bet...
ORGANISM(S): Homo sapiens 
2021-10-01 | E-MTAB-10318 | biostudies-arrayexpress
TranscriptomicsImmune status, strain background, and anatomic site of innoculation affect mouse papillomavirus (MmuPV1) induction of exophytic papillomas or endophytic trichoblastomas
Papillomaviruses (PVs) are able to induce papillomas, premalignant lesions, and carcinomas in a wide variety of species. PVs are classified first based on their host and tissue tropism and then their genomic diversities. A laboratory mouse papillomavirus, MmuPV1 (formerly MusPV), naturally infects N...
ORGANISM(S): Mus musculus 
2014-10-28 | E-GEOD-58094 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human acne lesion vs. normal skin from acne and non acne patients
The pathogenesis of acne has been linked to multiple factors such as increased sebum production, inflammation, follicular hyperkeratinization, and the action of Propionibacterium acnes within the follicle. In an attempt to understand the specific genes involved in inflammatory acne, we performed gen...
ORGANISM(S): Homo sapiens 
2008-06-14 | E-GEOD-6475 | biostudies-arrayexpress
TranscriptomicsExpression data from skin biopsy samples from patients with moderate-to-severe psoriasis
A gene expression profiling sub-study was conducted in which skin biopsy samples were collected from 85 patients with moderate-to-severe psoriasis who were participating in ACCEPT, an IRB-approved Phase 3, multicenter, randomized trial. This analysis identified 4,175 probe-sets as being significantl...
ORGANISM(S): Homo sapiens 
2012-07-25 | E-GEOD-30999 | biostudies-arrayexpress
TranscriptomicsRNA-seq of human skin lesions diagnosed as actinic keratosis, intraepidermal carcinoma or squamous cell carcinoma
We report whole tissue RNA-seq data captured from 25 AK, IEC or SCC lesions obtained from the skin of 17 individuals. We used RNA-seq to detect and measure HPV E7 transcription.
ORGANISM(S): Homo sapiens 
2018-07-09 | E-MTAB-6430 | biostudies-arrayexpress
ProteomicsSerum Proteomic Profiling Reveals Immune and Inflammatory Mechanisms Driving Susceptibility to Buffalo Fly-Induced Skin Lesions in Cattle
Buffalo fly (Haematobia irritans exigua) infestation in cattle poses a significant challenge to animal health and welfare, causing blood loss and often painful skin lesions. These lesions can reduce the value of cattle in saleyards, make cattle unacceptable for certain markets, and provide a focus f...
ORGANISM(S): Bos taurus (Bovine) 
2026-01-12 | PXD066231 | Pride
Acute phase response Susceptibility Buffalo fly (haematobia irritans exigua) Immune dysregulation Cattle Quantitative proteomics Biomarkers Skin lesions 
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