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ProteomicsDistinct Impact of Neuronal and Astrocytic IFNAR1 Loss in Parkinson-like Dementia
Interferon-alpha/beta-receptor (IFNAR) signal defects were recently identified to contribute to sporadic Parkinson’s disease (PD) with dementia (PDD). Mice lacking interferon-beta (IFNβ) develop PDD-like disease; however, the phenotypic, cellular, and molecular impacts of IFNAR1 loss in vivo have no...
ORGANISM(S): Mus musculus (Mouse) 
2026-06-08 | PXD037113 | Pride
Ifnar1 Glutamatergic neurotransmission Snrna-seq Parkinson’s disease dementia Lc-ms/ms 
ProteomicsSleep deprivation leads to non-adaptive alterations in sleep microarchitecture and amyloid-β accumulation in a murine Alzheimer model
Impaired sleep is a common aspect of aging and often precedes the onset of Alzheimer's disease. Here, we compare the effects of sleep deprivation in young wild-type mice and their APP/PS1 littermates, a murine model of Alzheimer's disease. After 7 h of sleep deprivation, both genotypes exhibit an in...
ORGANISM(S): Mus musculus (Mouse) 
2025-01-30 | PXD054763 | Pride
Proteomics Sleep Extracellular fluid Mouse Cerebrospinal fluid 
ProteomicsIntegrative Characterization of the R6/2 Mouse Brain Model of Huntington Disease Reveals Dysfunctional Neurotransmitter Metabolism
Huntington disease (HD) is a fatal neurodegenerative disease, where dysfunction and loss of striatal and cortical neurons are central to the pathogenesis of the disease. Here, we integrated quantitative studies to investigate the underlying mechanisms behind HD pathology in a systems-wide manner. To...
ORGANISM(S): Mus musculus (Mouse) 
2019-01-11 | PXD008099 | Pride
Huntington disease Glutamine and glutamate metabolism High resolution lc-ms Proteome Gs-ms Glutamatergic and gabaergic neurons 
ProteomicsHippocampal disruptions of synaptic and astrocyte metabolism during early amyloid pathology in the 5xFAD mouse model of Alzheimer’s disease
Alzheimer’s disease (AD) is an unremitting neurodegenerative disorder characterized by cerebral amyloid-β (Aβ) accumulation and gradual decline in cognitive function. Changes in brain energy metabolism arise in the preclinical phase of AD, suggesting an important metabolic component of early AD path...
ORGANISM(S): Mus musculus (Mouse) 
2021-11-09 | PXD025240 | Pride
Synaptosomes Hippocampus Ad Brain energy metabolism Seahorse Mitochondria Glucose Cerebral cortex 
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