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TranscriptomicsMurine hamatopoietic stem cell (HSC): wild type and Skp2 knockout
Transcriptional profiling of mouse HSC comparing wild type (WT) and Skp2 knockout Collected bone marrow (BM) cells from WT and Skp2 knockout mice, stained with HSC surface markers for FACS. Collected HSC and extracted total RNA then sent out for microarray analysis.
ORGANISM(S): Mus musculus 
2015-04-02 | E-GEOD-23064 | biostudies-arrayexpress
TranscriptomicsClinical relevance of SKP2 alterations in metastatic melanoma
Melanoma cell lines were genotyped to evaluate copy number differences between nodular melanoma (NM) and superficial spreading melanoma (SSM). Cell lines were also evaluated for copy number alterations in the SKP2/p27 axis. Affymetrix SNP arrays were performed according to manufacturer's instruction...
ORGANISM(S): Homo sapiens 
2010-10-21 | E-GEOD-22305 | biostudies-arrayexpress
ProteomicsThe purified SKP2 from HEK293T cells underwent LC-MS analysis.
Flag-tagged SKP2 was purified from HEK293T cells using anti-flag immunoprecipitation and subsequently analyzed via LC-MS to identify its interacting proteins.
ORGANISM(S): Homo sapiens (Human) 
2026-09-21 | PXD052608 | Pride
Skp2 
ProteomicsSKP2-affinity-purified mass spectrometry analysis.
This project aims to identify the SKP2 interaction proteins.
ORGANISM(S): Homo sapiens (Human) 
2023-01-05 | PXD039225 | Pride
Immunoprecipitation Skp2 Flag-tagged 
TranscriptomicsTranscription profiling of human MOLT4 cell lines before and after inhibition of gamma secretase to investigate NOTCH signaling in T-cell acute lymphoblastic leukemia cell lines
In T-cell acute lymphoblastic leukemia (T-ALL) NOTCH 1 receptors are frequently mutated. This leads to aberrantly high Notch signaling, but how this translates into deregulated cell cycle control and the transformed cell type is poorly understood. In this report, we analyze downstream responses resu...
ORGANISM(S): Homo sapiens 
2008-06-14 | E-GEOD-6495 | biostudies-arrayexpress
GenomicsMDAMB231 transcriptome response to SKP2 knockdown
MDAMB231 transcriptome response to SKP2 knockdown
PRJNA684918 | ENA
ProteomicsComprehensive single cell transcriptomics analysis of murine osteosarcoma uncovers Skp2 function in metastasis, genomic instability and immune activation and reveals additional target pathways
Osteosarcoma (OS) is the most common primary pediatric bone malignancy. One promising new therapeutic target is SKP2, encoding a substrate recognition factor of the SCF E3 ubiquitin ligase responsible for ubiquitination and proteasome degradation of substrate p27, thus driving cellular proliferation...
ORGANISM(S): Mus musculus (Mouse) 
2026-03-12 | PXD059605 | Pride
Osteosarcoma  skp2  single-cell rna-sequencing  tumor heterogeneity  immune infiltration  lineage plasticity 
Transcriptomicscomparison_col0vsskp2-Functional analysis of the SKP2 and CUL4 proteins
rs04-04_skp2_cul4 - comparison_col0vsskp2 - Antisense and mutants of the SKP2 and CUL4 genes are compared to the Wt in order to identify the genes controlled by those SCF proteins. - Comparison Col0 versus skp2 2 dye-swap - wt vs mutant comparison
ORGANISM(S): Arabidopsis thaliana 
2012-03-26 | E-GEOD-36651 | biostudies-arrayexpress
TranscriptomicsMDAMB231 transcriptome response to SKP2 knockdown
The SKP2 was knockdown by siRNAs in MDA-MB231 cells and RNA-Seq was used to define the transcriptome response to SKP2
ORGANISM(S): Homo sapiens 
2020-12-14 | GSE163110 | GEO
Transcriptomicscomparison_col0vsskp2-Functional analysis of the SKP2 and CUL4 proteins
rs04-04_skp2_cul4 - comparison_col0vsskp2 - Antisense and mutants of the SKP2 and CUL4 genes are compared to the Wt in order to identify the genes controlled by those SCF proteins. - Comparison Col0 versus skp2
ORGANISM(S): Arabidopsis thaliana 
2012-03-27 | GSE36651 | GEO
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