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ProteomicsNascent alt-protein chemoproteomics reveals a repressor of ribosome biogenesisNascent alt-protein chemoproteomics reveals a repressor of pre-60S assembly
Many unannotated microproteins and alternative proteins (alt-proteins) have recently been found to be co-encoded with canonical proteins, but few of their functions are known. Motivated by the hypothesis that alt-proteins undergoing regulated synthesis could play important cellular roles, we develop...
ORGANISM(S): Homo sapiens (Human) 
2022-09-13 | PXD026880 | Pride
Human hek 293t Lc-ms/ms 
ProteomicsLZTR1 is a Melanoma Oncogene that Promotes Cell Growth and Inhibits Apoptosis Under Stress
LZTR1 is known to act as a tumor suppressor in glioma, acting as an adaptor protein for Cullin 3 (CUL3) ubiquitin ligase. However, we demonstrated that LZTR1 is amplified in acral melanomas, and is required for melanoma cell proliferation and anchorage-independent growth. To understand the molecular...
ORGANISM(S): Homo sapiens (Human) 
2025-10-13 | PXD054157 | Pride
Autophagy Stress response Lztr1 Acral melanoma 
ProteomicsComparative proteomic profiling of unannotated microproteins and alternative proteins in human cell lines
Ribosome profiling and mass spectrometry have revealed thousands of small and alternative open reading frames (sm/alt-ORFs) that are translated into polypeptides variously termed microproteins and alt-proteins in mammalian cells. Some micro-/alt-proteins exhibit stress-, cell type- and/or tissue-spe...
ORGANISM(S): Homo sapiens (Human) 
2020-06-05 | PXD018565 | Pride
Alt-protein Proteogenomics Microprotein Smorf 
ProteomicsPhosphorylation of the NBDY microprotein promotes dissociation of biomolecular condensates
Proteogenomic identification of translated small open reading frames in human has revealed thousands of microproteins, or polypeptides of fewer than 100 amino acids, that were previously invisible to geneticists. Hundreds of microproteins have been shown to be essential for cell growth and prolifera...
ORGANISM(S): Homo sapiens (Human) 
2022-10-14 | PXD026098 | Pride
Phosphorylation Cell cycle Egf Nbdy 
ProteomicsThe ERVK3-1 microprotein interacts with the HUSH complex
Human endogenous retroviruses (hERVs) are molecular remnants of ancient retroviruses that integrated into the human germline and now make up 8% of the human genome. The human ERVK3-1 locus was recently annotated as encoding a 109-amino acid microprotein homologous to a retroviral Rec domain. ERVK3-1...
ORGANISM(S): Homo sapiens (Human) 
2025-08-25 | PXD064459 | Pride
Hervs Proximity labelling Lc-msms 
TranscriptomicsK562 polyA RNA-Seq
RNA-Seq reads and TopHat (Trapnell et al. Bioinformatics 2009) alignments of K562 cell-line transcriptome. These were used to validate the expression of short peptides idenitified by Mass-Spectrometry in K562 cells. K562 polyA+ RNA (Batch 1) and total RNA (batch 2) was purchased from Ambion. We use...
ORGANISM(S): Homo sapiens 
2012-11-14 | E-GEOD-34740 | biostudies-arrayexpress
ProteomicsMapping subcellular localizations of unannotated microproteins with MicroID
Proteogenomic and ribosome profiling identification of translated small open reading frames have revealed thousands of microproteins, or polypeptides of less than 100 amino acids, that were previously invisible to geneticists. However, the vast majority of microproteins remain uncharacterized in mol...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2022-08-01 | PXD033067 | Pride
Microprotein  proximity-dependent biotinylation 
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