Sort   by:  
 Page size 
ProteomicsSLC15A4 functions as a metabolic guardian of immune cells by controlling mTORC1 and AMPK
Solute carrier family 15 member A4 (SLC15A4) is a lysosome-resident amino acid/oligopeptide transporter preferentially expressed in immune cells, and plays critical roles in the pathogenesis of lupus and colitis in murine model. SLC15A4 is required for TLR7/9- or NOD1-mediated inflammatory responses...
ORGANISM(S): Homo sapiens (Human) 
2021-08-11 | PXD020370 | Pride
Slc15a4 bioid 
ProteomicsChemoproteomics-guided development of SLC15A4 inhibitors with anti-inflammatory activity
SLC15A4 is an endolysosome-resident transporter intimately linked with autoinflammation and autoimmunity. Specifically, SLC15A4 is critical for Toll-like receptor (TLR) 7-9 as well as the nucleotide-binding oligomerization domain-containing protein (NOD) signaling in several immune cell subsets. Not...
ORGANISM(S): Homo sapiens (Human) 
2023-11-29 | PXD045712 | Pride
Anti-inflammatory Chemoproteomics Slc15a4 
ProteomicsChemoproteomics-guided development of SLC15A4 inhibitors with anti-inflammatory activity
SLC15A4 is an endolysosome-resident transporter intimately linked with autoinflammation and autoimmunity. Specifically, SLC15A4 is critical for Toll-like receptor (TLR) 7-9 as well as the nucleotide-binding oligomerization domain-containing protein (NOD) signaling in several immune cell subsets. Not...
ORGANISM(S): Homo sapiens (Human) 
2023-11-29 | PXD045715 | Pride
Chemoproteomic Anti-inflammatory Slc15a4 
ProteomicsSLC15A4 (PHT1) interaction proteomics
Human genetics and mouse models provide compelling evidence for the involvement of SLC15A4 in endosomal TLR activation. To gain an understanding of the molecular mechanism, we set out to identify its binding partners by interaction proteomics. TAP-MS/MS analysis of different SLC15A4 protein variants...
ORGANISM(S): Homo sapiens (Human) 
2020-05-14 | PXD014254 | Pride
Human Slc Tap Cxorf21 Lc-ms/ms 
GenomicsTASL is the SLC15A4-associated adaptor for IRF5 activation by TLR7–9
TASL is the SLC15A4-associated adaptor for IRF5 activation by TLR7–9
PRJNA551037 | ENA
GenomicsImpact of SLC15A4, TASL and TASL2(Gm6377) deficiency on endolysosomal TLR7 and TLR9 responses
Impact of SLC15A4, TASL and TASL2(Gm6377) deficiency on endolysosomal TLR7 and TLR9 responses
PRJNA1112874 | ENA
TranscriptomicsTASL is the SLC15A4-associated adaptor for IRF5 activation by TLR7–9
Toll-like receptors (TLRs) have a crucial role in the recognition of pathogens and initiation of immune responses. Here we show that a previously uncharacterized protein encoded by CXorf21—a gene that is associated with systemic lupus erythematosus—interacts with the endolysosomal transporter SLC15A...
ORGANISM(S): Homo sapiens 
2020-05-13 | GSE133317 | GEO
TranscriptomicsImpact of SLC15A4, TASL and TASL2(Gm6377) deficiency on endolysosomal TLR7 and TLR9 responses
Nucleic acid sensing by endolysosomal TLR7-9 results in the induction of antiviral and proinflammatory transcriptional responses. We recently identified TASL as the innate immune adaptor mediating TLR7-9-induced IRF5 activation via the interaction with SLC15A4, but its relevance in primary murine ce...
ORGANISM(S): Mus musculus 
2024-11-04 | GSE267786 | GEO
UnknownSLC15A4 mediates M1-prone metabolic shifts in macrophages and guards immune cells from metabolic stress.
Not available
S-EPMC8379930 | biostudies-literature
UnknownTASL is the SLC15A4-associated adaptor for IRF5 activation by TLR7-9.
Not available
S-EPMC7610944 | biostudies-literature
Sort   by:  
 Page size