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ProteomicsProteomic changes in HepaRG cells exposed to mycotoxins, part 2
Proteomic changes associated with the individual and combined exposures of deoxynivalenol (DON) and zearalenone (ZEA) were investigated in human hepatocytes (HepaRG cell line) after 24 hour expousre and at low cytotoxicity levels using liquid chromatography coupled to tandem mass spectrometry.
ORGANISM(S): Homo sapiens (Human) 
2017-12-13 | PXD006267 | Pride
Mycotoxin 
TranscriptomicsReal-time transcriptional profiling of cellular and viral gene expression during lytic cytomegalovirus infection
During viral infections cellular gene expression is subject to rapid alterations induced by both viral and antiviral mechanisms. In this study, we applied metabolic labeling of newly transcribed RNA with 4-thiouridine (4sU-tagging) to dissect the real-time kinetics of cellular and viral transcriptio...
ORGANISM(S): Mus musculus 
2013-02-14 | E-GEOD-35833 | biostudies-arrayexpress
MetabolomicsMetabolomic analysis of the mechanism of action of yerba mate extract on Salmonella Typhimurium
Background: Salmonella Typhimurium is a gram-negative enteropathogen that infects millions worldwide; the rapid emergence of antibiotic resistant strains has heightened the urgency of developing effective treatment for this pathogen. Previous studies have demonstrated that the aqueous extract of yer...
2017-02-16 | MTBLS359 | MetaboLights
UnknownValidation of a Prediction Tool for Chemotherapy Toxicity in Older Adults With Cancer.
Not available
S-EPMC5321104 | biostudies-literature
ProteomicsProteomic changes in HepaRG cells exposed to mycotoxins
Proteomic changes associated with the individual and combined exposures of deoxynivalenol (DON) and zearalenone (ZEA) were investigated in human hepatocytes (HepaRG cell line) after only 1h exposure and at low cytotoxicity levels using liquid chromatography coupled to tandem mass spectrometry (LC-MS...
ORGANISM(S): Homo sapiens (Human) 
2017-12-13 | PXD005840 | Pride
Co-exposure Hepatocytes Human Deoxynivalenol Zearalenone Lc-ms/ms 
TranscriptomicsmiRNA profiling of human colon cells infected with the bacterium Shigella flexneri
Overview of microRNA expression changes during Shigella flexneri infection of human colon epithelial cells (HCT116)
ORGANISM(S): Homo sapiens 
2024-12-01 | E-MTAB-14092 | biostudies-arrayexpress
MetabolomicsUntargeted metabolomics profiling reveals exercise intensity-dependent alterations in Thoroughbred racehorses’ plasma after routine conditioning sessions

Thoroughbred (TB) racehorses are subjected to rigorous conditioning programs involving exercise sessions of various types, distances and intensities. These programs aim to optimize both their physical and mental capabilities, which are essential to achieve maximal performance. Conventional invest...

2024-01-16 | MTBLS8285 | MetaboLights
MetabolomicsHabitual Coffee Intake Shapes the Gut Microbiome and Modifies Host Physiology and Cognition: double-blind, randomised, parallel design

Coffee influences multiple physiological processes, including gut function, stress, cognition, and the microbiome. However, the mechanisms underlying these effects remain poorly understood. In this study, we examined coffee’s impact on the microbiota–gut–brain axis—a bidirectional communication p...

2026-03-26 | MTBLS13401 | MetaboLights
MetabolomicsAntiviral metabolite 3'-Deoxy-3',4'-didehydro-cytidine is detectable in serum and identifies acute viral infections including COVID-19

BACKGROUND: There is a critical need for rapid viral infection diagnostics to enable prompt case identification in pandemic settings and support targeted antimicrobial prescribing.

METHODS: Using untargeted high-resolution liquid chromatography coupled with...

2022-02-10 | MTBLS718 | MetaboLights
GenomicsGenome wide ChIP-seq analysis of human TOP2B occupancy in MCF7 breast cancer epithelial cells
TOP2B is involved in transcriptional initiation in response to nuclear hormone ligands and plays a role in transcriptional elongation. Whole genome TOP2B ChIP-seq was carried out on human MCF7 cells in the presence and absence of the nuclear hormone estradiol. Three peak calling methods were used an...
ORGANISM(S): Homo sapiens 
2015-09-21 | E-GEOD-66753 | biostudies-arrayexpress
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