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ProteomicsProteomic changes in HepaRG cells exposed to mycotoxins, part 2
Proteomic changes associated with the individual and combined exposures of deoxynivalenol (DON) and zearalenone (ZEA) were investigated in human hepatocytes (HepaRG cell line) after 24 hour expousre and at low cytotoxicity levels using liquid chromatography coupled to tandem mass spectrometry.
ORGANISM(S): Homo sapiens (Human) 
2017-12-13 | PXD006267 | Pride
Mycotoxin 
TranscriptomicsTranscription profiling of human coronary artery endothelial cells treated with ADMA at 2uM (a pathophysiological dose) and 100uM (a pharmacological dose), for 24h
Asymmetric dimethylarginine (ADMA) is a naturally occurring inhibitor of nitric oxide synthesis that accumulates in wide range of diseases associated with endothelial dysfunction and enhanced atherosclerosis. Plasma ADMA has been implicated as a major novel cardiovascular risk factor, but the mechan...
ORGANISM(S): Homo sapiens 
2005-09-01 | E-MEXP-377 | biostudies-arrayexpress
TranscriptomicsReal-time transcriptional profiling of cellular and viral gene expression during lytic cytomegalovirus infection
During viral infections cellular gene expression is subject to rapid alterations induced by both viral and antiviral mechanisms. In this study, we applied metabolic labeling of newly transcribed RNA with 4-thiouridine (4sU-tagging) to dissect the real-time kinetics of cellular and viral transcriptio...
ORGANISM(S): Mus musculus 
2013-02-14 | E-GEOD-35833 | biostudies-arrayexpress
ProteomicsProteomic changes in HepaRG cells exposed to mycotoxins
Proteomic changes associated with the individual and combined exposures of deoxynivalenol (DON) and zearalenone (ZEA) were investigated in human hepatocytes (HepaRG cell line) after only 1h exposure and at low cytotoxicity levels using liquid chromatography coupled to tandem mass spectrometry (LC-MS...
ORGANISM(S): Homo sapiens (Human) 
2017-12-13 | PXD005840 | Pride
Co-exposure Hepatocytes Human Deoxynivalenol Zearalenone Lc-ms/ms 
MetabolomicsMetabolomic analysis of the mechanism of action of yerba mate extract on Salmonella Typhimurium
Background: Salmonella Typhimurium is a gram-negative enteropathogen that infects millions worldwide; the rapid emergence of antibiotic resistant strains has heightened the urgency of developing effective treatment for this pathogen. Previous studies have demonstrated that the aqueous extract of yer...
2017-02-16 | MTBLS359 | MetaboLights
UnknownValidation of a Prediction Tool for Chemotherapy Toxicity in Older Adults With Cancer.
Not available
S-EPMC5321104 | biostudies-literature
TranscriptomicsTranscription profiling of Arabidopsis treated with sugars (glucose, mannose) and abcissic acid
The aim of the experiment is to determine sugar and ABA responsive gene expression in Arabidopsis.
ORGANISM(S): Arabidopsis thaliana 
2005-10-01 | E-MEXP-475 | biostudies-arrayexpress
GenomicsGenome wide ChIP-seq analysis of human TOP2B occupancy in MCF7 breast cancer epithelial cells
TOP2B is involved in transcriptional initiation in response to nuclear hormone ligands and plays a role in transcriptional elongation. Whole genome TOP2B ChIP-seq was carried out on human MCF7 cells in the presence and absence of the nuclear hormone estradiol. Three peak calling methods were used an...
ORGANISM(S): Homo sapiens 
2015-09-21 | E-GEOD-66753 | biostudies-arrayexpress
TranscriptomicsA Phase Two Randomised Controlled Trial of Belimumab in Kidney Transplant Recipients Demonstrates Comparable Safety, a Reduction in De Novo Antibody Production and an Increase in Regulatory B Cells.
There is an urgent unmet need in solid organ transplantation for immunotherapeutic strategies that target B cells and plasma cells, ideally without increasing infectious complications. We conducted a phase 2 double-blind randomised placebo-controlled trial to assess the safety and potential efficacy...
ORGANISM(S): Homo sapiens 
2018-06-11 | E-MTAB-5906 | biostudies-arrayexpress
UnknownThe Landscape of microRNA Targeting in Prostate Cancer Defined by AGO-PAR-CLIP.
Not available
S-EPMC4909715 | biostudies-literature
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