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ProteomicsA Novel Spectral Annotation Strategy Streamlines Reporting of mono-ADP-ribosylated Peptides Derived from Mouse Liver and Spleen in Response to IFN-gamma
Mass spectrometry-enabled ADP-ribosylation workflows are developing rapidly, providing researchers a variety of ADP-ribosylome enrichment strategies and mass spectrometric acquisition options. Despite the growth spurt in upstream technologies, systematic ADP-ribosyl (ADPr) peptide mass spectral anno...
ORGANISM(S): Mus musculus (Mouse) 
2021-11-02 | PXD027454 | Pride
Ifn-gamma Spleen Software Liver Adp-ribosylation Lc-ms/ms 
UnknownA mycobacterial phosphoribosyltransferase promotes bacillary survival by inhibiting oxidative stress and autophagy pathways in macrophages and zebrafish.
Not available
S-EPMC4505583 | biostudies-literature
ProteomicsHuman iPSCs differentiated into SMCs
Human iPSCs were differentiated towards an induced-SMC (iSMC) phenotype in a 10-day protocol. Proteomics was performed throughout the entire differentiation time course to provide a robust, well-defined starting and ending cell population. Proteomics data verified iPSC differentiation to iSMCs. Prot...
ORGANISM(S): Homo sapiens (Human) 
2022-10-14 | PXD032353 | Pride
Calcification Smooth muscle cell Lumos 
ProteomicsUbiquitination of protein Tau in Alzheimer's disease
Identification of posttranlational modifications of Tau in Alzheimer's disease
ORGANISM(S): Homo sapiens (Human) 
2022-05-19 | PXD031417 | Pride
Posttranslational modifications Tau Alzheimer's disease 
UnknownSatb2 acts as a gatekeeper for major developmental transitions during early vertebrate embryogenesis.
Not available
S-EPMC8526749 | biostudies-literature
ProteomicsSex-Dependent effects of Sortilin antisense oligonucleotide on Ldlr-/- mice
We evaluated the therapeutic potential of silencing sortilin expression in vivo using antisense oligonucleotide (ASO-Sort1) to reduce atherosclerosis and associated calcification. Male and female Ldl (low-density lipoprotein) receptor deficient mice were fed a high-fat diet and treated with ASO-Sort...
ORGANISM(S): Mus musculus (Mouse) 
2026-06-15 | PXD048883 | Pride
Sortilin Mouse Sex Ldlr Aortic arch Atherosclerosis 
ProteomicsSortilin Drives Valvular Interstitial Cells to a Combined Inflammatory Myofibroblast-Osteogenic Phenotype in Calcific Aortic Valve Disease as Revealed by Single-cell Analysis
Background: Calcific aortic valve disease (CAVD), the most common valve disease is comprised of a chronic interplay of inflammation, fibrosis, and calcification. In this study, sortilin (SORT1) was identified as a novel key player in the pathophysiology of CAVD, and its role in the transformation of...
ORGANISM(S): Homo sapiens (Human) 
2024-01-03 | PXD038117 | Pride
Calcification Aortic stenosis Sortilin Inflammation Single-cell rna sequencing Fibrosis 
UnknownOral Regimens for Rifampin-Resistant, Fluoroquinolone-Susceptible Tuberculosis.
Not available
S-EPMC7617355 | biostudies-literature
UnknownFactors Associated With Coronary Angiography Performed Within 6 Months of Randomization to the Conservative Strategy in the ISCHEMIA Trial.
Not available
S-EPMC11187765 | biostudies-literature
UnknownEvaluating the Appropriate Use Criteria for Coronary Revascularization in Stable Ischemic Heart Disease Using Randomized Data From the ISCHEMIA Trial.
Not available
S-EPMC11919559 | biostudies-literature
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