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ProteomicsPathogen and non-pathogen Spotted Fever Group Rickettsia trigger differential proteome signatures in macrophages
We have previously reported that Rickettsia conorii and Rickettsia montanensis have distinct intracellular fates within THP-1 macrophages, suggesting that the ability to proliferate within macrophages may be a distinguishable factor between pathogenic and non-pathogenic Spotted fever group (SFG) mem...
ORGANISM(S): Homo sapiens (Human) spotted fever group 
2019-02-16 | PXD010330 | Pride
Host-pathogen interactions Er quality control Rickettsia montanensis Macrophages Swath-ms Proteasome Infection Metabolic reprogramming Rickettsia conorii Spotted fever group rickettsia Protein processing pathways 
MetabolomicsA metabolic dependency for host isoprenoids in the obligate intracellular pathogen Rickettsia parkeri underlies a sensitivity for the statin class of host-targeted therapeutics
Gram-negative bacteria in the order Rickettsiales are obligate intracellular parasites that cause human diseases such typhus and spotted fever. They have evolved a dependence on essential nutrients and metabolites from the host cell as a consequence of extensive genome streamlining. However, it rema...
2019-10-31 | MTBLS846 | MetaboLights
ProteomicsEndothelial cell proteomic response to Rickettsia conorii infection
Rickettsia conorii is the etiologic agent of Mediterranean spotted fever, a re-emerging disease with significant mortality. This obligate, gram-negative intracellular pathogen is transmitted via tick bites, resulting in disseminated vascular endothelial cell infection with vascular leakage. In the ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-04-01 | MSV000080856 | MassIVE
TranscriptomicsGenomic comparison of virulent Rickettsia rickettsii Sheila Smith and avirulent Rickettsia rickettsii Iowa
Comparison of gene expression between the virulent Rickettsia rickettsii R strain and avirulent Rickettsia rickettsii Iowa. Keywords: virulent vs avirulent Virulent Rickettsia rickettsii R strain in triplicate was compared to avirulent Rickettsia rickettsii Iowa in triplicate
ORGANISM(S): Rickettsia rickettsii 
2010-05-26 | E-GEOD-8041 | biostudies-arrayexpress
TranscriptomicsR. conorii transcriptional response within inoculation eschar battlefield
Rickettsia conorii, the causative agent of the MSF is transmitted to humans by the bite of infected ticks Rhipicephalus sanguineus. The skin thus constitutes an important barrier for the entry and propagation of R. conorii. Given this, analysis of the survival strategies used by the bacterium within...
ORGANISM(S): Rickettsia conorii 
2008-11-06 | E-GEOD-12130 | biostudies-arrayexpress
GenomicsRickettsia massiliae MTU5
Spotted-fever group Rickettsia
PRJNA18271 | ENA
UnknownHuman Infection with Novel Spotted Fever Group Rickettsia Genotype, China, 2015.
Not available
S-EPMC5189162 | biostudies-literature
UnknownSpotted-fever group Rickettsia in Dermacentor variabilis, Maryland.
Not available
S-EPMC3320417 | biostudies-literature
UnknownDetection of Spotted Fever Group Rickettsia DNA by Deep Sequencing.
Not available
S-EPMC5652451 | biostudies-literature
UnknownSeroprevalence of typhus group and spotted fever group Rickettsia exposures on Reunion island.
Not available
S-EPMC6617902 | biostudies-literature
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