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ProteomicsSac1 interaction proteomics of ALFA Sac1 and mutants
Sphingolipids are structural membrane components that also function in cellular stress responses. The serine palmitoyl-transferase (SPT) catalyzes the rate limiting step in sphingolipid biogenesis. Its activity is tightly regulated through multiple bind-ing partners, including Tsc3, Orm proteins, ce...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2023-10-24 | PXD044586 | Pride
Sac1  s. cerevisiae  proteomics 
ProteomicsAn ERAD independent role for rhomboid pseudoprotease Dfm1 in mediating sphingolipid homeostasis
Nearly one-third of nascent proteins are initially targeted to the endoplasmic reticulum (ER) where they are correctly folded and assembled before being delivered to their final cellular destinations. To prevent the accumulation of misfolded membrane proteins, ER-associated-degradation (ERAD) remove...
ORGANISM(S): Saccharomyces Cerevisiae (ncbitaxon:4932) 
MSV000090333 | MassIVE
ProteomicsIdentification of distinct active pools of yeast serine palmitoyltransferase in sub-compartments of the ER.
Interaction proteomics of rewired serine palmitoyl transferase strains from Esch et al. 2023
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2023-12-01 | PXD047438 | Pride
Spt interaction proteomics 
ProteomicsAn Epstein–Barr Virus Protein Interaction Map Reveals NLRP3 Inflammasome Evasion Via MAVS UFMylation
Epstein-Barr virus (EBV) causes infectious mononucleosis, triggers multiple sclerosis and is associated with 200,000 cancers/year. EBV colonizes the B-cell compartment and periodically reactivates, inducing expression of 80 viral proteins. Yet much remains unknown about how EBV remodels host cells a...
ORGANISM(S): Viruses Homo sapiens (Human) 
2023-07-20 | PXD041336 | Pride
Innate immunity Gasdermin d Ufmylation Herpesvirus Mitochondrial-derived vesicles Herpesvirus replication Viral g-protein coupled receptor Nlrp3 inflammasome Antiviral defense Interactome Interleukin-1-beta 
GenomicsChIP-Seq sequencing of novel interactors of H3K4me3, H3K36me3 and H3K9me3
This study describes the epigenetic profiling of the novel interactors of H3K4me3, H3K36me3 or H3K9me3. The interactors were ChIP-Seq profiled by their GFP tag in stably transfected HeLa (Kyoto) cells. The interactors include GATAD1, Sgf29, BAP18, TRRAP, PHF8, N-PAC and LRWD1 (including replicates),...
ORGANISM(S): Homo sapiens 
2010-09-17 | E-GEOD-20303 | biostudies-arrayexpress
UnknownTransmembrane topology of mammalian ORMDL proteins in the endoplasmic reticulum as revealed by the substituted cysteine accessibility method (SCAM™).
Not available
S-EPMC6391742 | biostudies-literature
UnknownGlobal profiling of protein complex dynamics with an experimental library of protein interaction markers.
Not available
S-EPMC12440823 | biostudies-literature
UnknownProteomics Study Reveals the Anti-Depressive Mechanisms and the Compatibility Advantage of Chaihu-Shugan-San in a Rat Model of Chronic Unpredictable Mild Stress.
Not available
S-EPMC8802092 | biostudies-literature
ProteomicsProteomic signatures of Psychosocial Stress and Western Diet- driven Mitochondrial Dysfunction in Frontal Cortex and Hippocampus
Chronic Stress and Western diet are major risk factors for affective disorders, however their biological interactions remain unclear. This study examined the neurochemical, mitochondrial, metabolic, behavioural and proteomic effects of a chronic stress paradigm (2h/day for 2 weeks) in male C57bl/6 m...
ORGANISM(S): Mus musculus (Mouse) 
2026-05-25 | PXD074187 | Pride
Depression Mitochondria Stress Mouse Respiration Synaptogenesis Anxiety Western diet Co-morbidity 
ProteomicsNovel spliceosomal SF3B component in SAGA functions in transcriptional coactivation
MudPIT analyses of novel spliceosomal SF3B component in SAGA complex Stable Drosophila S2 cell lines expressing SF3B5 (CG11985, NP_652189.1), U2B (SNF; CG4528, NP_511045.1), Ada2b-PB (CG9638, NP_001027151.1), Spt3 (CG3169, NP_650146.1), Spt20 (CG17689, NP_648659.2), ATXN7 (CG9866, NP_722803.1), Ada1...
ORGANISM(S): Drosophila Melanogaster (ncbitaxon:7227) 
2016-03-21 | MSV000079597 | MassIVE
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