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ProteomicsSchizophrenia risk gene ZNF804A controls ribosome localization and synaptogenesis in developing human neurons
Large-scale genomic screenings greatly advanced our understanding of the genetic basis of schizophrenia. However, how this translates into neurobiological functioning is not clear. Therefore, we aimed to characterize the function of robust susceptibility gene zinc finger protein 804A (ZNF804A), usin...
ORGANISM(S): Homo sapiens (Human) 
2026-03-31 | PXD047788 | Pride
Ribosomes Compartment seperation assay Schizophrenia Data-independent acquisition Synaptogenesis 
ProteomicsProteomic analysis links truncated tau to lysosome motility, autophagy and endo-lysosomal dysfunction
Tauopathies are characterized by the progressive accumulation of abnormal tau species, which disrupt the autophagy-lysosomal pathway (ALP), a critical system for degrading intracellular macromolecules and aggregated proteins, causing toxicity and cell death. This study investigates the impact of the...
ORGANISM(S): Mus musculus (Mouse) 
2025-12-22 | PXD062128 | Pride
Tauopathies Toxicity Proteomics Mass spectrometry Autosomal 
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