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ProteomicsA quantitative map of beta-lactone induced virulence regulation
Beta-lactones have recently been introduced as the first selective ClpP inhibitors that attenuate virulence of both sensitive Staphylococcus aureus and multiresistant strains (MRSA). Although previous knockout studies showed that ClpP is essential for S. aureus alpha-toxin production a link between ...
ORGANISM(S): Staphylococcus aureus 
2017-02-08 | PXD004680 | Pride
Proteomics Chemical knockout S. aureus clpp Antivirulence Activity-based protein profiling 
ProteomicsA whole proteome inventory of background photocrosslinker binding
Affinity based protein profiling (AfBPP) is a widely applied methodology for target identification of bioactive molecules. Photocrosslinkers such as benzophenone, diazirine and aryl azide irreversibly link the molecule of interest to its dedicated target protein upon irradiation with UV light. Despi...
ORGANISM(S): Homo sapiens (Human) 
2016-12-05 | PXD004009 | Pride
Affinity-based protein profiling Photocrosslinker Target identification 
ProteomicsRab1b-AMPylation by Legionella DrrA is allosterically activated by Rab1
Legionella pneumophila infect eukaryotic cells by forming a replicative organelle – the Legionella containing vacuole. During this process, the bacterial protein DrrA/SidM is secreted and manipulates the activity and posttranslational modification (PTM) states of the vesicular trafficking regulator ...
ORGANISM(S): Legionella pneumophila Homo sapiens (Human) 
2021-01-04 | PXD019043 | Pride
Crosslink Legionella Rab Drra 
ProteomicsA network of chaperones prevents and detects failures in membrane protein lipid bilayer integration
A fundamental step in membrane protein biogenesis is their integration into the lipid bilayer with a defined topology. Despite this, it remains unclear how cells detect and handle failures in membrane integration. Our data show that single point mutations in the membrane protein connexin 32 (Cx32), ...
ORGANISM(S): Homo sapiens (Human) 
2019-01-29 | PXD009189 | Pride
Protein quality control Connexin Endoplasmic reticulum Topology Membrane protein Er membrane complex Chaperone Protein degradation Protein folding 
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