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ProteomicsMulti-omics Dissection of MAPK-driven Senescence Unveils Therapeutic Vulnerabilities in KIAA1549::BRAF-fusion Pediatric Low-Grade Glioma Models
This study investigates molecular mechanisms regulating oncogene-induced senescence (OIS) and senescence-associated secretory phenotype (SASP) in pediatric low-grade gliomas (pLGGs). Using multi-omics analysis of a pilocytic astrocytoma cell line, we identified key OIS effectors and pathways affecte...
ORGANISM(S): Homo sapiens (Human) 
2025-06-30 | PXD060126 | Pride
Senescence-associated secretory phenotype Mapk pathway Multi-omics Oncogene-induced senescence Mapk inhibitor Pediatric low-grade glioma 
ProteomicsMapping the castor bean endosperm proteome revealed a metabolic interaction between plastid, mitochondria, and peroxisomes to optimize seedling growth
The aim of the project was to elucidate the inter-organellar interplay of plastids, mitochondria, and peroxisomes during storage reserve mobilization in the endosperm to supply the growing seedling with nutrients upon germination. Organelles from endosperm of etiolated castor bean seedlings were iso...
ORGANISM(S): Ricinus communis 
2024-01-09 | PXD040932 | Pride
Proteomic study Storage reserve mobilization Inter-organellar interplay Metabolic network Metabolism 
UnknownA Preliminary Study of a Lettuce-Based Edible Vaccine Expressing the Cysteine Proteinase of Fasciola hepatica for Fasciolosis Control in Livestock.
Not available
S-EPMC6244665 | biostudies-literature
UnknownFirst Toxoplasma gondii isolate from an aborted foetus of European bison (Bison bonasus bonasus L.).
Not available
S-EPMC5548833 | biostudies-literature
ProteomicsProteome analysis of HepG2 WT and mitochondrial apolipoprotein MIC26 knockout cells under normo- and hyperglycemic conditions
Increased amounts of the mitochondrial apolipoprotein O /MIC26 were found in diabetic patients along with lipid accumulation in murine liver upon MIC26 expression. MIC26 is a MICOS complex constituent present in the mitochondrial inner membrane. Here, we employed a proteomics analysis approach in W...
ORGANISM(S): Homo sapiens (Human) 
2024-09-13 | PXD047246 | Pride
Apolipoproteins Mic26 Mitochondria Micos complex and fatty acid metabolism 
ProteomicsM.abscessus Proteome and Secretome
Members of the Mycobacterium (M.) abscessus complex (MABC) are rapidly growing mycobacteria showing smooth and/or rough colony morphotype. While not as virulent as M. tuberculosis, they can cause soft tissue infection and fatal pulmonary disease, especially in patients with cystic fibrosis. Diagnosi...
ORGANISM(S): Mycobacterium abscessus 
2022-01-19 | PXD010504 | Pride
Lc-ms Non tuberculous mycobacteria Secretome Mycobacterium abscessus Proteomics M.abscessus Cystic fibrosis 
GenomicsChIP-seq of three core components of the circadian clock (BMAL1, CLOCK and CRY1) in unsynchronized human U2OS cells
The human osteosarcoma cell line U2OS contains a functional circadian clock but expresses only a few rhythmic genes. We identified by ChIP-seq analysis 3040 binding sites of the circadian transcription factors BMAL1, CLOCK, and CRY1 in the genome of U2OS cells, comparable to the number found in high...
ORGANISM(S): Homo sapiens 
2016-02-11 | E-GEOD-44236 | biostudies-arrayexpress
UnknownColitis promotes adaptation of an intestinal nematode: a Heligmosomoides polygyrus mouse model system.
Not available
S-EPMC3805612 | biostudies-literature
UnknownA regularization corrected score method for nonlinear regression models with covariate error.
Not available
S-EPMC3622191 | biostudies-literature
UnknownThe Immunological Properties of Recombinant Multi-Cystatin-Like Domain Protein From Trichinella Britovi Produced in Yeast.
Not available
S-EPMC6797592 | biostudies-literature
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