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ProteomicsSystematic proteomic analysis of LRRK2-mediated Rab GTPase phosphorylation establishes a connection to ciliogenesis
We previously reported that Parkinson’s disease (PD) kinase LRRK2 phosphorylates a subset of Rab GTPases on a conserved residue in their switch-II domains (Steger, Tonelli et al., 2016) (PMID: 26824392). Here, we systematically analyzed the Rab protein family and found 14 of them (Rab3A/B/C/D, Rab5A...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2017-11-14 | PXD007214 | Pride
Proteomics Rabgtpases Lrrk2 Parkinson's disease 
ProteomicsPhosphoproteomics reveals that Parkinson’s disease kinase LRRK2 regulates a subset of Rab GTPases
Mutations in Park8, encoding for the multidomain Leucine-rich repeat kinase 2 (LRRK2) protein, comprise the predominant genetic cause of Parkinson’s disease (PD). G2019S, the most common amino acid substitution activates the kinase two to three-fold. This has motivated the development of LRRK2 kinas...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2016-02-04 | PXD003071 | Pride
Lrrk2 Substrates Phosphoproteomics Rab gtpases 
ProteomicsLeucine-973 is a Crucial Residue Differentiating Insulin and IGF-1 Receptor Signaling
Insulin and IGF-1 receptors (IR/IGF1R) are highly homologous and share similar signaling systems, but each has a unique physiological role, with IR primarily regulating metabolic homeostasis and IGF1R regulating mitogenic control and growth. Here, we show that replacement of a single amino acid at p...
ORGANISM(S): Mus musculus (Mouse) 
2022-12-21 | PXD038649 | Pride
Phosphoproteomics Ir Insulin Igfr 
TranscriptomicsH4K12 acetylation in Human Spermatozoa
H4K12 acetylation mapped by chromatin Chromatin immunoprecipitation (ChIP) in human sperm. ChIP mapping of chromatin modification. Three biological replicates hybridized to each of two chips.
ORGANISM(S): Homo sapiens 
2010-05-18 | E-GEOD-13101 | biostudies-arrayexpress
ProteomicsThe natural diversity of the yeast proteome links aneuploidy tolerance to protein turnover
Accessing the natural genetic diversity of species unveils hidden genetic traits, clarifies gene functions, and allows assessment of the generalizability of laboratory findings. One notable discovery made in Saccharomyces cerevisiae natural isolates is frequent (~20%) aneuploidy – an imbalance in ch...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2024-03-13 | PXD048219 | Pride
Aneuploidy Protein stability Yeast Silac 
ProteomicsRobust dimethyl-based multiplex-DIA doubles single-cell proteome depth via a reference channel
Single-cell proteomics aims to characterize biological function and heterogeneity at the level of proteins in an unbiased manner. It is currently limited in proteomic depth, throughput, and robustness, which we address here by a streamlined multiplexed workflow using data-independent acquisition (mD...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2022-12-22 | MSV000090956 | MassIVE
UnknownAdjuvant Palbociclib for Early Breast Cancer: The PALLAS Trial Results (ABCSG-42/AFT-05/BIG-14-03).
Not available
S-EPMC10476784 | biostudies-literature
UnknownAdjuvant Pertuzumab and Trastuzumab in Early HER2-Positive Breast Cancer.
Not available
S-EPMC5538020 | biostudies-literature
UnknownTrastuzumab for early-stage, HER2-positive breast cancer: a meta-analysis of 13 864 women in seven randomised trials.
Not available
S-EPMC8324484 | biostudies-literature
UnknownIncreasing the dose intensity of chemotherapy by more frequent administration or sequential scheduling: a patient-level meta-analysis of 37 298 women with early breast cancer in 26 randomised trials.
Not available
S-EPMC6451189 | biostudies-literature
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