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TranscriptomicsTranscription profiling of S. pombe reveals Cyclin dependent kinase inhibits re-initiation of a normal S-phase program during G2
To achieve faithful replication of the genome once in each cell cycle, re-initiation of S-phase is prevented in G2 and origins are restricted from re-firing within S-phase. We have investigated the block to re-replication during G2 in fission yeast. The DNA synthesis that occurs when G2/M cyclin d...
ORGANISM(S): Schizosaccharomyces pombe 
2009-05-13 | E-MTAB-105 | biostudies-arrayexpress
ProteomicsIdentification of Protein Targets of S-nitroso-Coenzyme A-Mediated S-Nitrosation Using Chemoproteomics
S-nitrosation is a cysteine post-translational modification (PTM) fundamental to cellular signaling. This modification regulates protein function in numerous biological processes in the nervous, cardiovascular, and immune systems. Small molecule or protein nitrosothiols act as mediators of NO signal...
ORGANISM(S): Homo sapiens (Human) 
2024-01-03 | PXD048172 | Pride
S-nitrosation  chemoproteomics  s-nitroso-coenzyme a 
TranscriptomicsTranscription profiling of human bronchial epithelial cells stimulated with the commensal bacterium S. salivarius K12 of the pathogens S. aureus, P. aeruginosa, or S. enteritidis
Human bronchial epithelial cells (16HBE14O-) were stimulated with the commensal bacterium S. salivarius K12, or the pathogens S. aureus, P. aeruginosa, or S. enteritidis (subtype Typhimurium) for 1 hour.
ORGANISM(S): Homo sapiens 
2008-10-30 | E-FPMI-13 | biostudies-arrayexpress
ProteomicsUHPLC-MS/MS analysis of S-nitrosylated proteins involved in autophagy in Triticum aestivum roots
In the present work, we analyzed the patterns of protein S-nitrosylation during the inductionof autophagy in сommon wheat (Triticum aestivum) roots. S-nitrosylated proteins were accumulated in plant tissues as a result of artificially induced autophagy, visualized usingWestern blot and identified by...
ORGANISM(S): Triticum aestivum (Wheat) 
2023-12-31 | PXD044484 | Pride
Autophagy Nitric oxide S-nitrosylation of proteins Triticum aestivum 
ProteomicsS-Nitrosylation-mediated dysfunction of TCA cycle enzymes in synucleinopathy studied in postmortem human brains and hiPSC-derived neurons
A causal relationship between mitochondrial metabolic dysfunction and neurodegeneration has been strongly implicated in synucleinopathies, including Parkinson’s disease (PD) and Lewy body dementia (LBD), but the underlying molecular basis is not fully understood. Here, using human induced pluripoten...
ORGANISM(S): Homo sapiens (Human) 
2024-10-17 | PXD036797 | Pride
S-nitrosylation Alpha-synuclein Tca cycle Mitochondrial dysfunction 
UnknownMass marking of juvenile Schizothorax wangchiachii (Fang) with alizarin red S and evaluation of stock enhancement in the Jinping area of the Yalong River.
Not available
S-EPMC5723138 | biostudies-literature
ProteomicsHPLC-MS/MS analysis of the S-monooxygenated S-Trp (O=S-Trp) bearing peptide in EcKatG S-Trp105
A sulfur-containing analog of tryptophan, thiotryptophan (3-benzothienyl-L-alanine, S-Trp), was genetically incorporated into EcKatG to replace the MYW-forming tryptophan, W105. The S-Trp-bearing peptide was isolated using trypsin digestion followed by HPLC separation. Tandem mass spectrometry (MS/M...
ORGANISM(S): Escherichia coli 
2026-05-13 | PXD078006 | Pride
Catalase-peroxidase Non-canical amino acid Katg 
ProteomicsMetabolic bypass partially rescues S-nitrosylation-induced TCA cycle inhibition and synapse loss in Alzheimer’s disease human neurons
In Alzheimer’s disease (AD), dysfunctional mitochondrial metabolism has been associated with synaptic loss, the major pathological correlate of cognitive decline. Mechanistic insight for this relationship, however, is still lacking. Here, comparing isogenic wild-type and AD mutant human induced plur...
ORGANISM(S): Homo sapiens (Human) 
2024-05-24 | PXD042436 | Pride
S-nitrosylation Alzheimer’s disease Mitochondrial metabolism Tca cycle inhibition 
ProteomicsHPLC-MS/MS analysis of the S-monooxygenated S-Trp (O=S-Trp) bearing peptide in heme reconstituted EcKatG S-Trp105
A sulfur-containing analog of tryptophan, thiotryptophan (3-benzothienyl-L-alanine, S-Trp), was genetically incorporated into EcKatG to replace the MYW-forming tryptophan, W105. The heme free apo-protein was purified, after heme-reconstitution and peroxide treatment, the S-Trp-bearing peptide was is...
ORGANISM(S): Escherichia coli 
2026-05-13 | PXD078069 | Pride
Catalase-peroxidase Non-canical amino acid Katg 
ProteomicsComparison of SPEED, S-Trap, and In-Solution based sample preparation methods for tandem mass spectrometry
Bottom-up proteomic analyses rely on efficient protein extraction from tissue and proteolysis into peptides for mass spectrometry. Commonly used detergent-based strategies aid cell lysis and protein solubilization but are poorly compatible with downstream protein digestion and liquid chromatography-...
ORGANISM(S): Ovis aries 
2023-03-30 | PXD030797 | Pride
Speed Plasma Kidney Sheep Tripletof S-trap Dda 
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